{"id":"W1482511868","doi":"10.1128/jvi.00560-15","title":"Artificial Recruitment of UAF1-USP Complexes by a PHLPP1-E1 Chimeric Helicase Enhances Human Papillomavirus DNA Replication","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Biology; Helicase; Origin recognition complex; DNA replication; Deubiquitinating enzyme; Control of chromosome duplication; DNA; Minichromosome maintenance; Ubiquitin; Replication factor C; Cell biology; Molecular biology; Genetics; Eukaryotic DNA replication; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002869955,0.0003905216,0.0002438847,0.0001664275,0.0001613926,0.000442585,0.0002921949,0.0003580814,0.001250012],"category_scores_gemma":[0.0002348076,0.0001827903,0.0002587612,0.0001331501,0.0002998641,0.0002313741,0.0004543398,0.000484518,0.0004404204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005164871,"about_ca_system_score_gemma":0.0001885368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003087334,"about_ca_topic_score_gemma":0.0004340929,"domain_scores_codex":[0.9997622,0.00004384234,0.00002641427,0.00005691753,0.00005418321,0.00005630139],"domain_scores_gemma":[0.9997633,0.00006757223,0.0000625535,0.00002797085,0.00001568471,0.00006281048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001264805,0.00004177602,0.0002125762,0.00003240977,0.000005657846,0.00002637692,0.00001098799,0.00006702913,0.9986381,0.00005161366,0.00001877307,0.0007681914],"study_design_scores_gemma":[0.00001112213,0.0001098416,0.001952913,0.000004765747,0.000008562823,0.0001362678,0.00001098088,0.0008478676,0.995745,0.00001181732,0.001157774,0.000003068309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964354,0.001053833,0.001674872,0.00005536527,0.00001277533,0.00001880232,0.0001597591,0.00006383129,0.0005252738],"genre_scores_gemma":[0.9957975,0.0003445838,0.002460999,0.00003064025,0.000006130832,0.0000242078,0.0004076392,0.00002057238,0.0009078021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001250012,"threshold_uncertainty_score":0.004181683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09266839566835781,"score_gpt":0.3499800448559437,"score_spread":0.2573116491875859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}