{"id":"W1482523072","doi":"10.1038/90615","title":"Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product","year":2001,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":257,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; BC Cancer Agency; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Montreal Clinical Research Institute","funders":"Institut National de la Santé et de la Recherche Médicale; Association pour la Recherche sur le Cancer","keywords":"Signal transduction; Cell biology; Signal transducing adaptor protein; Proto-oncogene tyrosine-protein kinase Src; Biology; Tyrosine kinase; SH2 domain; Tyrosine phosphorylation; Cell signaling; Protein tyrosine phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001390341,0.000389345,0.000154074,0.0001843807,0.000208109,0.0005122713,0.0001407502,0.000204519,0.0009580785],"category_scores_gemma":[0.0001593579,0.0001086519,0.0001907295,0.0001030239,0.0002991688,0.0003034226,0.0004205137,0.0006902257,0.0005387258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004158577,"about_ca_system_score_gemma":0.0001273909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002639651,"about_ca_topic_score_gemma":0.0002838325,"domain_scores_codex":[0.9998263,0.00003529129,0.000008299919,0.00002385932,0.00003045548,0.00007572959],"domain_scores_gemma":[0.9998355,0.00004149246,0.00004546195,0.00001628149,0.00002167085,0.00003965677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001366279,0.000009866023,0.0001495153,0.00001273722,0.000001008073,0.00005141946,0.00001473847,0.00003061569,0.9983451,0.0002475047,0.00004310995,0.0009578058],"study_design_scores_gemma":[0.00002548807,0.0001798152,0.01020095,0.000006166559,0.000006087142,0.0003044601,0.00008003981,0.002141664,0.9853202,0.0002853256,0.001444084,0.000005801494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942968,0.001191053,0.002378914,0.00009931462,0.0000290486,0.000007665679,0.0001326922,0.00007069519,0.001793748],"genre_scores_gemma":[0.9968755,0.0002829191,0.0009854535,0.00004147969,0.00001109827,0.00001068378,0.000268129,0.00001638787,0.001508306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009580785,"threshold_uncertainty_score":0.003205121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005559947064033597,"score_gpt":0.2180959427943093,"score_spread":0.2125359957302757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}