{"id":"W1482523072","doi":"10.1038/90615","title":"Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product","year":2001,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":257,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; BC Cancer Agency; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Montreal Clinical Research Institute","funders":"Institut National de la Santé et de la Recherche Médicale; Association pour la Recherche sur le Cancer","keywords":"Signal transduction; Cell biology; Signal transducing adaptor protein; Proto-oncogene tyrosine-protein kinase Src; Biology; Tyrosine kinase; SH2 domain; Tyrosine phosphorylation; Cell signaling; Protein tyrosine phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003040888,0.0002308271,0.0003142777,0.0001608338,0.0002698503,0.00001062359,0.0002358055,0.0007912543,0.004792177],"category_scores_gemma":[0.0001479525,0.0001685205,0.0001335415,0.0003676791,0.0003726552,0.000189884,0.00002900199,0.001047516,0.0003376496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009491994,"about_ca_system_score_gemma":0.0000709688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007604076,"about_ca_topic_score_gemma":0.000009140557,"domain_scores_codex":[0.9982932,0.0004847256,0.0004775321,0.0003622476,0.00006374523,0.0003185334],"domain_scores_gemma":[0.9988081,0.0001676504,0.0003005309,0.0003825603,0.0003312324,0.000009891331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001385205,0.0001542886,0.0002680759,0.000004552375,0.0003525509,7.172681e-7,0.0004000854,0.00001340582,0.9687954,0.0003971192,0.02382098,0.004407618],"study_design_scores_gemma":[0.001488551,0.0002978593,0.01191217,0.00001178674,0.00005624174,0.0003437226,0.00022707,0.00002100295,0.7581327,0.00009846969,0.2272532,0.0001572095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9500452,0.03206462,0.001168599,0.004496634,0.008705353,0.0008330631,0.00002561929,0.0001887279,0.002472198],"genre_scores_gemma":[0.9854101,0.0007357198,0.00002757796,0.0003729732,0.0001081826,0.00004131786,0.0009898061,0.00002193675,0.01229239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2106627,"threshold_uncertainty_score":0.9961176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005559947064033597,"score_gpt":0.2180959427943093,"score_spread":0.2125359957302757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}