{"id":"W1482617484","doi":"10.4049/jimmunol.166.5.3174","title":"Ligation of 4-1BB (CDw137) Regulates Graft-Versus-Host Disease, Graft-Versus-Leukemia, and Graft Rejection in Allogeneic Bone Marrow Transplant Recipients","year":2001,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research & Development Corporation","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Memorial Sloan-Kettering Cancer Center","keywords":"CD8; T cell; Leukemia; Immunology; Bone marrow; Cytotoxic T cell; CD28; Graft-versus-host disease; Splenocyte; Transplantation; Cancer research; Medicine; Biology; Immune system; Internal medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001052034,0.000375674,0.0007854509,0.0005806998,0.0002555405,0.0000128431,0.0005501186,0.0005462015,0.0001980563],"category_scores_gemma":[0.0001703852,0.0002824955,0.0002226226,0.0004536607,0.001041612,0.0002637605,0.0001292392,0.0009710946,0.00004624218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002137656,"about_ca_system_score_gemma":0.000181858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004172228,"about_ca_topic_score_gemma":0.0004222313,"domain_scores_codex":[0.9967275,0.001001771,0.001215867,0.0003142015,0.0001115492,0.0006291142],"domain_scores_gemma":[0.9976323,0.0006294571,0.0009725243,0.000485426,0.000228593,0.00005166556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02308385,0.0002833151,0.008747293,0.0000192549,0.0007960885,0.00006579622,0.001150554,0.00004597841,0.9625645,0.0002357647,0.0002903176,0.002717329],"study_design_scores_gemma":[0.0426487,0.008112752,0.3813821,0.0007253145,0.001835224,0.005062063,0.003336525,0.00003670641,0.5395551,0.002302066,0.01384147,0.00116196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698556,0.02535796,0.00004835444,0.001090204,0.00318349,0.0002713436,0.0000202091,0.00002869162,0.000144145],"genre_scores_gemma":[0.9806427,0.01823799,0.00004405234,0.00005364149,0.00006615882,0.00000853089,0.00005358585,0.00003289371,0.0008604255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4230093,"threshold_uncertainty_score":0.9999627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228470242953559,"score_gpt":0.2211014019295588,"score_spread":0.2088166995000233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}