{"id":"W1482790870","doi":"10.4049/jimmunol.1402132","title":"Newly Recruited CD11b+, GR-1+, Ly6Chigh Myeloid Cells Augment Tumor-Associated Immunosuppression Immediately following the Therapeutic Administration of Oncolytic Reovirus","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Oncolytic virus; Immunosuppression; Immune system; Cancer research; Myeloid; Haematopoiesis; Immunology; Progenitor cell; Myeloid-derived Suppressor Cell; Oncolytic adenovirus; Biology; Medicine; Cancer; Stem cell; Suppressor; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008271133,0.0002128677,0.0002102811,0.0001667248,0.00006978101,0.0002135059,0.00008158916,0.0001527886,0.001065573],"category_scores_gemma":[0.00009593394,0.00006079623,0.0001113471,0.00006831204,0.0001197339,0.0001496379,0.0001448417,0.0005804603,0.0002613734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009598244,"about_ca_system_score_gemma":0.0001362804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001073177,"about_ca_topic_score_gemma":0.0002798455,"domain_scores_codex":[0.9999079,0.0000183943,0.000008981026,0.00001770816,0.00001778544,0.00002931612],"domain_scores_gemma":[0.9999144,0.00001668383,0.0000282324,0.00001049741,0.000006812969,0.00002330561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001610991,0.00003064043,0.0002053627,0.00002246684,0.000001201859,0.00002966375,0.00001422186,0.00003652774,0.9971356,0.00005871709,0.00001662504,0.002287865],"study_design_scores_gemma":[0.00001559078,0.001157646,0.005341479,0.000006888265,0.00001376306,0.0003466273,0.00003179299,0.0004540657,0.99027,0.00004513191,0.002313619,0.000003370032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955187,0.001243685,0.002085307,0.00004136307,0.00002411214,0.00003382506,0.0001027247,0.00005443039,0.0008959342],"genre_scores_gemma":[0.9953126,0.000854848,0.001784094,0.00004037041,0.00002283826,0.00003596582,0.0001671169,0.00001219663,0.001769972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065573,"threshold_uncertainty_score":0.003564715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03518820833600431,"score_gpt":0.3096612096459813,"score_spread":0.274473001309977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}