{"id":"W1482790870","doi":"10.4049/jimmunol.1402132","title":"Newly Recruited CD11b+, GR-1+, Ly6Chigh Myeloid Cells Augment Tumor-Associated Immunosuppression Immediately following the Therapeutic Administration of Oncolytic Reovirus","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Oncolytic virus; Immunosuppression; Immune system; Cancer research; Myeloid; Haematopoiesis; Immunology; Progenitor cell; Myeloid-derived Suppressor Cell; Oncolytic adenovirus; Biology; Medicine; Cancer; Stem cell; Suppressor; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002832049,0.0002292357,0.0004010698,0.000100373,0.0001694379,0.00003005807,0.0009259009,0.0002038603,0.00003004806],"category_scores_gemma":[0.0003310108,0.0001369936,0.0002737795,0.0002667482,0.000258846,0.00001588033,0.0001833374,0.0005131329,0.000009288123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001257824,"about_ca_system_score_gemma":0.001036472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005159199,"about_ca_topic_score_gemma":0.00007343682,"domain_scores_codex":[0.9964828,0.001639022,0.0008014924,0.0001747444,0.0004990053,0.0004028954],"domain_scores_gemma":[0.9976562,0.0002164868,0.0008947895,0.0006414332,0.000504767,0.00008629241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008143296,0.0002186033,0.00008771876,0.000004655747,0.0007557324,0.00002466697,0.0005261899,0.000188688,0.9866961,0.000005300916,0.0005623805,0.002786665],"study_design_scores_gemma":[0.002756216,0.008651122,0.001253149,0.00006405757,0.0001523088,0.0002047158,0.001404971,0.00003747583,0.9834842,0.0001666269,0.001669773,0.0001553884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827558,0.0147157,0.0001177491,0.001169014,0.0007904458,0.0002890388,0.000007751041,0.00000636795,0.0001481719],"genre_scores_gemma":[0.9975859,0.00149777,0.00006031925,0.0003363568,0.0001669107,0.000008863748,0.00002362398,0.00003551885,0.0002847715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01483011,"threshold_uncertainty_score":0.5586438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03518820833600431,"score_gpt":0.3096612096459813,"score_spread":0.274473001309977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}