{"id":"W1482949914","doi":"10.1111/j.1755-5949.2011.00246.x","title":"Screening of Therapeutic Strategies for Huntington's Disease in YAC128 Transgenic Mice","year":2011,"lang":"en","type":"review","venue":"CNS Neuroscience & Therapeutics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria; Island Health","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Huntington's disease; Transgene; Genetically modified mouse; Disease; Huntingtin; Medicine; Neuroscience; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003815015,0.0009873956,0.001620775,0.000652509,0.000291478,0.0002269844,0.002381029,0.0002178637,0.000021892],"category_scores_gemma":[0.0001616784,0.000869692,0.0009509164,0.001678156,0.001136724,0.0004031809,0.0001742433,0.0005578464,0.0000084355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004753156,"about_ca_system_score_gemma":0.00133923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008967996,"about_ca_topic_score_gemma":0.000007840718,"domain_scores_codex":[0.9942496,0.0008334559,0.001275044,0.001882099,0.0006382148,0.001121566],"domain_scores_gemma":[0.9967804,0.000852666,0.000835575,0.001123859,0.0001053731,0.0003021364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002194293,0.001313387,0.0001182208,0.01134198,0.0000409281,0.00001550437,0.0009215116,0.0005001384,0.08600686,0.008333112,0.00001662209,0.8911723],"study_design_scores_gemma":[0.00106548,0.0007385469,0.0003026705,0.003752925,0.002135544,0.00001243387,0.0001273589,0.001264779,0.03429361,0.002555643,0.9515784,0.002172594],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004662599,0.9804624,0.008217712,0.00005397528,0.001479866,0.00411543,0.0006419435,0.000161471,0.0002046526],"genre_scores_gemma":[0.04890373,0.9485223,0.0002389836,0.001366302,0.0001114313,0.0004600635,0.00001121648,0.0002082683,0.0001776578],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9515618,"threshold_uncertainty_score":0.9993754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2202869950722943,"score_gpt":0.3745818257939341,"score_spread":0.1542948307216398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}