{"id":"W1482949914","doi":"10.1111/j.1755-5949.2011.00246.x","title":"Screening of Therapeutic Strategies for Huntington's Disease in YAC128 Transgenic Mice","year":2011,"lang":"en","type":"review","venue":"CNS Neuroscience & Therapeutics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria; Island Health","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Huntington's disease; Transgene; Genetically modified mouse; Disease; Huntingtin; Medicine; Neuroscience; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007500934,0.001234473,0.001132848,0.001066526,0.0003161739,0.0005563791,0.0009062958,0.001069966,0.001701134],"category_scores_gemma":[0.000268678,0.0004166921,0.0007550324,0.0004737111,0.0003190922,0.0004146368,0.0002997764,0.001764074,0.001005426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004972469,"about_ca_system_score_gemma":0.0003611982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004385946,"about_ca_topic_score_gemma":0.0006804236,"domain_scores_codex":[0.9996181,0.00005718106,0.00004865387,0.00007333272,0.0001235126,0.00007936291],"domain_scores_gemma":[0.9997833,0.00005134843,0.0000619583,0.00002089441,0.00003412326,0.00004839363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002899303,0.0002746338,0.00009733023,0.0002419498,0.00002856784,0.000139546,0.00002042052,0.0002070176,0.9923365,0.0002718248,0.0002959228,0.005796505],"study_design_scores_gemma":[0.0005032723,0.005790389,0.001880282,0.0001257934,0.000224323,0.0009400042,0.00003417072,0.001293461,0.9661015,0.0001923069,0.02288054,0.00003387385],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9035935,0.03854642,0.03813526,0.001118458,0.0005322872,0.002474773,0.004898042,0.001517689,0.009183513],"genre_scores_gemma":[0.8597813,0.05023109,0.05732002,0.0006003414,0.0002043902,0.00501864,0.01054534,0.0004351868,0.01586382],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001701134,"threshold_uncertainty_score":0.005690873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2202869950722943,"score_gpt":0.3745818257939341,"score_spread":0.1542948307216398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}