{"id":"W1483119271","doi":"10.1111/j.1365-2958.2011.07785.x","title":"The Caulobacter crescentus chromosome replication origin evolved two classes of weak DnaA binding sites","year":2011,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"DnaA; Caulobacter crescentus; Biology; DNA replication; Origin of replication; SeqA protein domain; Pre-replication complex; Genetics; Origin recognition complex; Circular bacterial chromosome; DNA-binding protein; Conserved sequence; Cell biology; DNA; Eukaryotic DNA replication; Cell cycle; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002232366,0.0002258172,0.0002288374,0.00006560321,0.0001161429,0.00001672381,0.0005172235,0.0003905487,0.0000424159],"category_scores_gemma":[0.00008793333,0.0001734587,0.0001392415,0.0001434217,0.0004079741,0.000002834814,0.0002773462,0.0001366825,0.00002797188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001987207,"about_ca_system_score_gemma":0.00006465266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004542257,"about_ca_topic_score_gemma":0.0001006578,"domain_scores_codex":[0.998459,0.0001399457,0.0003785901,0.0005644363,0.0000422244,0.0004157395],"domain_scores_gemma":[0.9985387,0.00001394503,0.0002379757,0.001017129,0.0001397087,0.00005259013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001013571,0.00006117742,0.001981331,0.000008777924,0.0001077652,0.000003383788,0.00001673988,5.869129e-7,0.9957636,0.0006217337,0.0006130209,0.0007205338],"study_design_scores_gemma":[0.0004123832,0.0003408444,0.0009109294,0.000007718518,0.00002998339,0.00006113163,0.00002306572,0.000002945207,0.8916694,0.00008915693,0.1062667,0.0001857224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970506,0.001220515,0.0003141527,0.000246784,0.0002974696,0.0002703231,0.00005742995,0.00002360423,0.0005191261],"genre_scores_gemma":[0.9973882,0.0005192214,0.001210626,0.0001339567,0.00008732767,0.0000227828,0.0003805431,0.00003116125,0.0002261682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1056537,"threshold_uncertainty_score":0.707344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01581997530746331,"score_gpt":0.2443537264119738,"score_spread":0.2285337511045105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}