{"id":"W1483119271","doi":"10.1111/j.1365-2958.2011.07785.x","title":"The Caulobacter crescentus chromosome replication origin evolved two classes of weak DnaA binding sites","year":2011,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"DnaA; Caulobacter crescentus; Biology; DNA replication; Origin of replication; SeqA protein domain; Pre-replication complex; Genetics; Origin recognition complex; Circular bacterial chromosome; DNA-binding protein; Conserved sequence; Cell biology; DNA; Eukaryotic DNA replication; Cell cycle; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002074714,0.000925682,0.0004701297,0.0005744066,0.0002432528,0.0004451524,0.0006258275,0.0005387893,0.0007165617],"category_scores_gemma":[0.0003419361,0.0004163131,0.0004696583,0.0003078481,0.0003915288,0.0002631751,0.0004719005,0.0008660412,0.0005809067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008258019,"about_ca_system_score_gemma":0.0005815753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005261471,"about_ca_topic_score_gemma":0.004620737,"domain_scores_codex":[0.999683,0.00001870897,0.00001816184,0.0001131431,0.0001040147,0.00006300839],"domain_scores_gemma":[0.9995271,0.00005467504,0.0001149959,0.0001026987,0.0000707628,0.0001298315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004919034,0.00001637223,0.000338666,0.0000214312,0.000002964902,0.00002696329,0.000006748959,0.0000338149,0.9984639,0.00006597768,0.00001415726,0.0009598323],"study_design_scores_gemma":[0.0000255883,0.0001600065,0.01497582,0.000009214786,0.00001772325,0.0005644843,0.00002456676,0.001023599,0.9804829,0.00009135906,0.002604434,0.00002020074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892341,0.001987335,0.006584941,0.00009949029,0.00002780169,0.00005735143,0.0005935019,0.0002609022,0.001154625],"genre_scores_gemma":[0.9847302,0.0003399702,0.008807214,0.00007734447,0.000007702916,0.00004859969,0.002082734,0.00007890584,0.003827301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005261471,"threshold_uncertainty_score":0.01046169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01581997530746331,"score_gpt":0.2443537264119738,"score_spread":0.2285337511045105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}