{"id":"W1483289789","doi":"","title":"Abstract 15852: PKR-Like Endoplasmic Reticulum Kinase (PERK) and Glycogen Synthase Kinase (GSK)-3α/β Signaling Regulate Atherosclerosis Development","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Unfolded protein response; GSK-3; ATF6; Endoplasmic reticulum; Thapsigargin; GSK3B; Cell biology; Kinase; Protein kinase R; EIF-2 kinase; Signal transduction; Medicine; Endocrinology; Protein kinase A; Biology; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537189,0.0005942298,0.0003219297,0.0002834771,0.0001954219,0.0004339646,0.0002305063,0.0003321939,0.008675949],"category_scores_gemma":[0.00008230151,0.0001858906,0.0003209466,0.0002329434,0.0002574963,0.0003871364,0.0003345129,0.0008893454,0.002542927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00029571,"about_ca_system_score_gemma":0.0003507807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003017454,"about_ca_topic_score_gemma":0.000461528,"domain_scores_codex":[0.9999152,0.00001017006,0.000008311906,0.00002477216,0.00002218284,0.00001925152],"domain_scores_gemma":[0.9999157,0.000005002129,0.00003558433,0.000005773977,0.000009448352,0.00002848743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001499446,0.0000959528,0.0007797765,0.000507522,0.00002874283,0.0003959958,0.0000297015,0.0001273172,0.9831901,0.0008054521,0.001597225,0.01094289],"study_design_scores_gemma":[0.0008733424,0.001722545,0.05575223,0.0001965664,0.0002172327,0.002991604,0.0001880165,0.001667903,0.8777316,0.001263388,0.0573616,0.00003403193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9089706,0.04494716,0.008383137,0.003203748,0.000879108,0.0001950867,0.005783082,0.001142506,0.02649555],"genre_scores_gemma":[0.9180558,0.01968678,0.008446276,0.0008703584,0.0003229507,0.0002838634,0.00537286,0.0001235274,0.04683771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008675949,"threshold_uncertainty_score":0.029024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100826573206786,"score_gpt":0.2164250290748335,"score_spread":0.2063423717541549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}