{"id":"W1483299903","doi":"10.4049/jimmunol.168.10.4897","title":"4-1BB Ligand-Mediated Costimulation of Human T Cells Induces CD4 and CD8 T Cell Expansion, Cytokine Production, and the Development of Cytolytic Effector Function","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":211,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CD28; Cytotoxic T cell; Interleukin 21; IL-2 receptor; Natural killer T cell; CD8; T cell; Biology; ZAP70; Antigen-presenting cell; Cytokine; Interleukin 12; CD137; Interleukin 3; Cell biology; Molecular biology; Cytolysis; Immunology; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001140838,0.0002093244,0.0005887254,0.0002242624,0.0003380123,0.000006441376,0.0002604641,0.0002707456,0.0001103282],"category_scores_gemma":[0.000176073,0.0001174684,0.00006936969,0.0001895933,0.001269934,0.0001058122,0.0001201459,0.0005258828,0.00002584528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002806358,"about_ca_system_score_gemma":0.00004897064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002969061,"about_ca_topic_score_gemma":0.0000126844,"domain_scores_codex":[0.9978132,0.000742711,0.000975206,0.0001590691,0.00006908258,0.000240779],"domain_scores_gemma":[0.9976081,0.0006803428,0.00112572,0.0002660861,0.0003044679,0.00001525727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001324145,0.0002103785,0.0003154869,0.00004069376,0.0004262632,8.179119e-7,0.00409593,0.00001524471,0.9913187,0.0000389094,0.0003303874,0.001883043],"study_design_scores_gemma":[0.004292375,0.001092717,0.005295106,0.00008224256,0.0002614454,0.0002299696,0.0009360577,0.000006143701,0.9868702,0.0001187043,0.0006958811,0.0001192103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819177,0.01637652,0.0000774267,0.0004025283,0.0008393489,0.0003104258,0.000003635382,0.00001138186,0.00006102183],"genre_scores_gemma":[0.9980301,0.001431711,0.00004164176,0.00003385682,0.00004369091,0.000004762544,0.000008877684,0.00001462631,0.0003906909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01611243,"threshold_uncertainty_score":0.4790224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01251706023480851,"score_gpt":0.208924508724902,"score_spread":0.1964074484900935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}