{"id":"W1483299903","doi":"10.4049/jimmunol.168.10.4897","title":"4-1BB Ligand-Mediated Costimulation of Human T Cells Induces CD4 and CD8 T Cell Expansion, Cytokine Production, and the Development of Cytolytic Effector Function","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":211,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CD28; Cytotoxic T cell; Interleukin 21; IL-2 receptor; Natural killer T cell; CD8; T cell; Biology; ZAP70; Antigen-presenting cell; Cytokine; Interleukin 12; CD137; Interleukin 3; Cell biology; Molecular biology; Cytolysis; Immunology; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002494753,0.0006130916,0.0004454619,0.0002874038,0.0001471871,0.0004109753,0.0001730869,0.0003304176,0.002717273],"category_scores_gemma":[0.0002243209,0.0002377484,0.0002994944,0.0002731724,0.0001666077,0.0002291383,0.0003142453,0.0007774138,0.0008353995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003780918,"about_ca_system_score_gemma":0.0003023683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004603511,"about_ca_topic_score_gemma":0.0006188597,"domain_scores_codex":[0.9995059,0.0001392681,0.00003634429,0.00008275366,0.00008895146,0.0001467351],"domain_scores_gemma":[0.999889,0.00003582596,0.00001449041,0.00002288401,0.00001354067,0.00002409737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004000167,0.0001238031,0.00022617,0.00006025489,0.00001057324,0.00007771801,0.00004239267,0.0002075116,0.9943131,0.0000690114,0.0001575178,0.004311828],"study_design_scores_gemma":[0.0001764132,0.001615246,0.003818289,0.00002502331,0.00005254034,0.0004941657,0.000050132,0.002705957,0.9816785,0.0001437777,0.009228037,0.00001203123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911,0.002040679,0.002892945,0.00009064597,0.00004777914,0.0001039887,0.000286924,0.0001154384,0.003321602],"genre_scores_gemma":[0.9905038,0.0009204908,0.003816524,0.0001086905,0.00004817873,0.0001473998,0.000875546,0.00002715062,0.003552221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002717273,"threshold_uncertainty_score":0.009090245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01251706023480851,"score_gpt":0.208924508724902,"score_spread":0.1964074484900935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}