{"id":"W1483319096","doi":"10.4049/jimmunol.171.1.69","title":"Thy-1 Signaling in the Context of Costimulation Provided by Dendritic Cells Provides Signal 1 for T Cell Proliferation and Cytotoxic Effector Molecule Expression, but Fails to Trigger Delivery of the Lethal Hit","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Cytotoxic T cell; Cell biology; Perforin; T cell; Granzyme B; CD28; Granzyme; Effector; Biology; Cytolysis; Antigen-presenting cell; Chemistry; Immunology; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120384,0.0004173868,0.0002545289,0.0001141982,0.000128838,0.0004450205,0.0001699176,0.0003794258,0.00096447],"category_scores_gemma":[0.0001215663,0.0001183883,0.000207648,0.0001103118,0.0001966488,0.0002378935,0.0002111631,0.0008529554,0.0004220618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003621472,"about_ca_system_score_gemma":0.0003303527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003260744,"about_ca_topic_score_gemma":0.0005630353,"domain_scores_codex":[0.9998012,0.0000364498,0.0000155217,0.00003441913,0.00004065564,0.00007178915],"domain_scores_gemma":[0.9998627,0.00004005765,0.0000355893,0.00001922304,0.00001018145,0.00003222304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003901387,0.00001291273,0.00008321538,0.00001882457,0.000001681034,0.00002272198,0.000005834145,0.00004004661,0.9994507,0.0000436191,0.00001080735,0.0002706315],"study_design_scores_gemma":[0.00001025445,0.0001176649,0.0006212756,0.000003009121,0.000009181893,0.0001164738,0.00001012975,0.0003399443,0.9979402,0.00001679237,0.0008130274,0.000001956271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997483,0.0006141142,0.0009746326,0.0000715652,0.00002505196,0.00001144624,0.000110424,0.00002704738,0.0006827755],"genre_scores_gemma":[0.9968875,0.0003965746,0.001298804,0.00003832399,0.0000127874,0.00001754764,0.0002426472,0.000007955033,0.001097803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00096447,"threshold_uncertainty_score":0.003226459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008872169469722148,"score_gpt":0.2259491433617098,"score_spread":0.2170769738919877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}