{"id":"W1483464410","doi":"10.1177/135965350701200405","title":"Plasma Concentrations of the HIV-Protease Inhibitor Lopinavir are Suboptimal in Children Aged 2 Years and Below","year":2007,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University Health Centre","funders":"","keywords":"Cmin; Lopinavir; Pharmacokinetics; Cmax; Lopinavir/ritonavir; Medicine; Regimen; Ritonavir; Human immunodeficiency virus (HIV); Area under the curve; Pharmacology; Internal medicine; Viral load; Immunology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001423471,0.0001076685,0.0001781324,0.00006027136,0.00004981689,0.000008018927,0.00004936675,0.00005286648,0.00001757871],"category_scores_gemma":[0.0000115574,0.00007375459,0.00005100481,0.0001866526,0.0001088659,0.00005823711,0.00001717067,0.0001152156,0.000009703248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002845559,"about_ca_system_score_gemma":0.00005113073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002113522,"about_ca_topic_score_gemma":0.00002913859,"domain_scores_codex":[0.9993088,0.00003212189,0.0001878339,0.0001477614,0.0001487165,0.0001748218],"domain_scores_gemma":[0.9997104,0.00002668988,0.00007175417,0.0001337051,0.00001874469,0.00003870939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002008961,0.0001970377,0.9876556,0.000004167303,0.00005365813,0.00002243089,0.0006890568,3.377698e-7,0.004522782,0.0000560893,0.0003014716,0.00629642],"study_design_scores_gemma":[0.003530209,0.00006594144,0.9517524,0.00008540662,0.00001218711,0.000009036337,0.000108378,0.000006937593,0.04397892,0.00001616945,0.0003587529,0.00007564403],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979957,0.0002329914,0.000008540857,0.0008262401,0.00003807392,0.0006330029,0.00001542578,0.00001483746,0.0002351947],"genre_scores_gemma":[0.9982191,0.0001833546,0.0003657332,0.00009774293,0.0000495772,0.000009065999,0.00002399668,0.00001102844,0.001040393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03945614,"threshold_uncertainty_score":0.3007624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134162018512606,"score_gpt":0.2518263873898143,"score_spread":0.2404847672046883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}