{"id":"W1483658947","doi":"10.1593/neo.07947","title":"Pharmacological Inhibition of DNA Methylation Induces Proinvasive and Prometastatic Genes In Vitro and In Vivo","year":2008,"lang":"en","type":"article","venue":"Neoplasia","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Demethylating agent; Cancer research; Biology; DNA methylation; Cell growth; DNA demethylation; Cell cycle; Metastasis; Molecular biology; Cell; Cancer; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508555,0.00008249257,0.0001267441,0.00009437511,0.00002305912,0.000004511057,0.0000216021,0.00009168663,0.000004214533],"category_scores_gemma":[0.0000564968,0.00007736328,0.00001432264,0.0001088489,0.00007142041,0.000006785973,0.00003260326,0.00005381403,2.048086e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007155012,"about_ca_system_score_gemma":0.00003306105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001557617,"about_ca_topic_score_gemma":0.00004630332,"domain_scores_codex":[0.999353,0.00008093342,0.0001964172,0.0001969623,0.00007203907,0.0001006525],"domain_scores_gemma":[0.9997919,0.00002552827,0.00007270924,0.00005088825,0.0000273016,0.00003163507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009606482,0.00005029083,0.01336407,0.00002327155,0.000006662982,0.000005988345,0.0001874596,0.00003080819,0.982908,0.000004462455,0.000003506821,0.003319483],"study_design_scores_gemma":[0.0006557942,0.0001472463,0.05364161,0.000008631003,0.00000723,0.000008316554,0.00004945052,0.00008662132,0.9450738,0.0001855142,0.00006173267,0.00007402679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976892,0.001811933,0.00007097381,0.00004337174,0.00002010332,0.0002484026,0.000007818417,0.000002526228,0.0001056505],"genre_scores_gemma":[0.9973699,0.001419284,0.00110152,0.00001761189,0.000022642,0.00002480608,0.00002382596,0.000006138805,0.00001425353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04027755,"threshold_uncertainty_score":0.3154783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205199977330722,"score_gpt":0.2676303174520329,"score_spread":0.2471103197189607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}