{"id":"W1483658947","doi":"10.1593/neo.07947","title":"Pharmacological Inhibition of DNA Methylation Induces Proinvasive and Prometastatic Genes In Vitro and In Vivo","year":2008,"lang":"en","type":"article","venue":"Neoplasia","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Demethylating agent; Cancer research; Biology; DNA methylation; Cell growth; DNA demethylation; Cell cycle; Metastasis; Molecular biology; Cell; Cancer; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001509771,0.0003195288,0.000227318,0.0002319169,0.00008933264,0.0001688251,0.0001609178,0.0001513359,0.00106056],"category_scores_gemma":[0.0001245658,0.0001291958,0.000176972,0.0001138177,0.0001749304,0.00008539144,0.00008853123,0.0004605874,0.000180021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000227626,"about_ca_system_score_gemma":0.0001784191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006556926,"about_ca_topic_score_gemma":0.001326163,"domain_scores_codex":[0.99989,0.00002194207,0.000007613245,0.0000204083,0.00002434538,0.00003568669],"domain_scores_gemma":[0.9999285,0.00002145062,0.00001799091,0.00001036272,0.000007529187,0.00001418597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000117278,0.00004713613,0.00008258617,0.00002386623,0.000006744104,0.0000122901,0.000006641256,0.00005431455,0.9983147,0.00005683757,0.00002066187,0.001257007],"study_design_scores_gemma":[0.00002138786,0.001241982,0.001677657,0.00000370818,0.00001836765,0.00008257333,0.000009996191,0.0004316467,0.9951664,0.00002865833,0.001315626,0.000001936655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900094,0.00456317,0.002679937,0.00009002178,0.0000372391,0.00004920401,0.0002343994,0.0001037532,0.002232838],"genre_scores_gemma":[0.9942385,0.002389916,0.001254967,0.00004736119,0.00001342039,0.0000463478,0.0004093073,0.00001177287,0.001588485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00106056,"threshold_uncertainty_score":0.003547907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205199977330722,"score_gpt":0.2676303174520329,"score_spread":0.2471103197189607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}