{"id":"W1484172713","doi":"10.1371/journal.pone.0128278","title":"EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Zhejiang Province; University of British Columbia; National Natural Science Foundation of China; National Science Foundation","keywords":"Leukotriene B4; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Chemistry; Receptor; Inflammation; Cell biology; Internal medicine; Endocrinology; Signal transduction; Pharmacology; Biology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001848639,0.0004745737,0.0004375815,0.000271529,0.0001582077,0.0002224528,0.000162041,0.0003177489,0.001405234],"category_scores_gemma":[0.0001386438,0.0002059365,0.0004548298,0.0001586643,0.0002125304,0.0002453608,0.0002016196,0.0006479535,0.0003317075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002169574,"about_ca_system_score_gemma":0.0002343129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000794658,"about_ca_topic_score_gemma":0.0008211046,"domain_scores_codex":[0.9998722,0.00002262435,0.00001793229,0.00001558258,0.00002083152,0.00005084978],"domain_scores_gemma":[0.9999325,0.000008328817,0.00001993951,0.000006041029,0.000009499903,0.00002366124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001813876,0.0004077085,0.0002526679,0.0001325948,0.0000261176,0.0001087931,0.00004376266,0.0001239617,0.9936264,0.00008855911,0.0001022775,0.003273464],"study_design_scores_gemma":[0.0002067987,0.003455431,0.00842002,0.00001723445,0.00008121928,0.0002195063,0.00009007646,0.001929583,0.9831482,0.00008360237,0.002338085,0.00001026222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944951,0.00311817,0.001099029,0.0001667121,0.00005054724,0.00002312348,0.000174523,0.00007319413,0.0007996545],"genre_scores_gemma":[0.9905067,0.003314616,0.001439926,0.0001295466,0.0000434636,0.00008376485,0.0005046111,0.00001342316,0.003964021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001405234,"threshold_uncertainty_score":0.004701018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03411831686432976,"score_gpt":0.2377872397718149,"score_spread":0.2036689229074851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}