{"id":"W148429787","doi":"10.1016/j.cbpc.2017.06.004","title":"Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug/multixenobiotic resistance (MDR/MXR) functional activity in the model teleost, Danio rerio (zebrafish)","year":2017,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Pregnane X receptor; Zebrafish; Multidrug resistance-associated protein 2; Danio; Biology; CYP3A; Cytochrome P450; Constitutive androstane receptor; Efflux; Pharmacology; Multiple drug resistance; P-glycoprotein; Cell biology; ATP-binding cassette transporter; Nuclear receptor; Gene; Transporter; Biochemistry; Enzyme; Transcription factor; Drug resistance; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008816476,0.0002452357,0.0002329587,0.0003031901,0.0002026659,0.0002592094,0.0001334672,0.0002969132,0.002307336],"category_scores_gemma":[0.0001101692,0.0002672972,0.0003216888,0.0001072657,0.0004427652,0.0002739901,0.0002595279,0.0004559091,0.0003802394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006199781,"about_ca_system_score_gemma":0.0002392371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004163693,"about_ca_topic_score_gemma":0.006275059,"domain_scores_codex":[0.9998814,0.0000114659,0.00000685406,0.00003923774,0.00001960683,0.00004141206],"domain_scores_gemma":[0.9999075,0.000008908753,0.00003357079,0.000009396498,0.00001557004,0.00002498889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000270993,0.00001305923,0.0005870365,0.00001810337,0.000004241361,0.00005628924,0.00003581516,0.00002843723,0.998092,0.0001782698,0.00006366586,0.0006520401],"study_design_scores_gemma":[0.0001214746,0.0007335175,0.1621978,0.00001885872,0.00007935667,0.0004533347,0.0004469142,0.001125438,0.8299887,0.0002870899,0.004505206,0.00004226407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971719,0.0005197143,0.0005334084,0.0001009224,0.00001566638,0.000008657197,0.0004173253,0.00004141698,0.001191009],"genre_scores_gemma":[0.9914682,0.0002489823,0.0005292428,0.00007817051,0.000005908884,0.00003393204,0.0004216885,0.00002880761,0.007185014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004163693,"threshold_uncertainty_score":0.008278906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04338081971352034,"score_gpt":0.316676600470513,"score_spread":0.2732957807569927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}