{"id":"W1485033931","doi":"10.1186/ar1489","title":"Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production","year":2005,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Hôpital du Sacré-Cœur de Montréal; Hôpital Notre-Dame; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Protein kinase A; p38 mitogen-activated protein kinases; Kinase; Chemistry; Protein kinase B; Mitogen-activated protein kinase kinase; Cell biology; Chondrocyte; Nitric oxide synthase; cGMP-dependent protein kinase; Nitric oxide; ASK1; Molecular biology; Phosphorylation; Biochemistry; Biology; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266435,0.0003371032,0.0003891722,0.000262527,0.0001562475,0.0002411711,0.0001168179,0.0002641781,0.0008579697],"category_scores_gemma":[0.0001390313,0.0001825502,0.0004008664,0.0002316312,0.0002113547,0.0001599836,0.0001968308,0.000504234,0.0002645681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001999294,"about_ca_system_score_gemma":0.0001905294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006749218,"about_ca_topic_score_gemma":0.001364716,"domain_scores_codex":[0.999691,0.00004603972,0.00003889888,0.00004128337,0.0001083869,0.00007451081],"domain_scores_gemma":[0.9998555,0.00002732415,0.00003194498,0.00001673002,0.00002202805,0.00004644042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006356521,0.0000162788,0.00009199368,0.00002906452,0.000001841985,0.00005788688,0.00001083328,0.000005711122,0.9994387,0.000006760524,0.000005846206,0.000271552],"study_design_scores_gemma":[0.00006353052,0.0009863175,0.0296856,0.00001872251,0.00002929024,0.0006800524,0.0001017834,0.0004473635,0.966774,0.00005630576,0.001146727,0.00001036596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925382,0.004839789,0.001222404,0.00006278158,0.00006089151,0.00003452673,0.00021734,0.00002412866,0.0009999281],"genre_scores_gemma":[0.9926831,0.002577824,0.001704017,0.00007879948,0.00004481598,0.00005996538,0.0003545194,0.000005674579,0.002491174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008579697,"threshold_uncertainty_score":0.002870202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03347963928774416,"score_gpt":0.3225603439901973,"score_spread":0.2890807047024531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}