{"id":"W1485033931","doi":"10.1186/ar1489","title":"Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production","year":2005,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Hôpital du Sacré-Cœur de Montréal; Hôpital Notre-Dame; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Protein kinase A; p38 mitogen-activated protein kinases; Kinase; Chemistry; Protein kinase B; Mitogen-activated protein kinase kinase; Cell biology; Chondrocyte; Nitric oxide synthase; cGMP-dependent protein kinase; Nitric oxide; ASK1; Molecular biology; Phosphorylation; Biochemistry; Biology; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001951005,0.000251236,0.0004397988,0.0009321717,0.0002609304,0.00007708975,0.0001123981,0.0001401214,0.0001377148],"category_scores_gemma":[0.001702012,0.000228489,0.00008362152,0.001222567,0.0003525954,0.0004188836,0.00004010279,0.0005673632,0.0001564516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195358,"about_ca_system_score_gemma":0.0002294591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001640031,"about_ca_topic_score_gemma":0.0003728998,"domain_scores_codex":[0.9967845,0.0004814788,0.0004473596,0.0007275233,0.0007549957,0.0008041181],"domain_scores_gemma":[0.9984602,0.0003946971,0.00005857919,0.0005010756,0.0003201347,0.0002652629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001264327,0.0004423835,0.006889437,0.00007795273,0.00003674212,0.0001107666,0.0005878979,0.00003684343,0.5640845,0.00004073108,0.001200579,0.4252278],"study_design_scores_gemma":[0.01212781,0.001511095,0.02801821,0.001375482,0.00001662267,0.001227467,0.001144825,0.0001937736,0.9185423,0.00112891,0.03415835,0.0005551131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550644,0.03768811,0.000002788715,0.00447684,0.0001214352,0.00210028,0.000006238557,0.0001159938,0.0004239842],"genre_scores_gemma":[0.9249556,0.07002377,0.0007427915,0.000193624,0.0008041466,0.0003173444,0.00001235649,0.00005754983,0.002892817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4246727,"threshold_uncertainty_score":0.9317512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03347963928774416,"score_gpt":0.3225603439901973,"score_spread":0.2890807047024531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}