{"id":"W1485352707","doi":"10.1186/1471-2474-4-2","title":"Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model","year":2003,"lang":"en","type":"article","venue":"BMC Musculoskeletal Disorders","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université de Moncton","funders":"National Institute of Dental and Craniofacial Research; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University of Toronto; Dairy Farmers of Canada; Geriatric Research Education and Clinical Center; U.S. Department of Agriculture","keywords":"Hyperhomocysteinemia; Internal medicine; Endocrinology; Osteoporosis; Homocysteine; Osteopenia; Medicine; Cystathionine beta synthase; Cortical bone; Osteocalcin; Homocystinuria; Bone mineral; Bone remodeling; Bone growth; Bone density; Methionine; Chemistry; Anatomy; Biochemistry; Alkaline phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001689616,0.0001457972,0.0002571759,0.000191838,0.00002242593,0.000009554799,0.00005746375,0.0001009486,0.00004351734],"category_scores_gemma":[0.0001599447,0.0001312283,0.000101457,0.0002859787,0.0001188115,0.0001607509,0.00003605685,0.0001429069,0.000004636601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002738029,"about_ca_system_score_gemma":0.0001304703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001882589,"about_ca_topic_score_gemma":0.0000277702,"domain_scores_codex":[0.998801,0.00006905646,0.0002730955,0.0003220495,0.0002665306,0.0002683043],"domain_scores_gemma":[0.9994004,0.00002178041,0.00003959669,0.0002342764,0.00004366908,0.0002602504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004430429,0.000595809,0.05547158,0.0004962154,0.000009116884,0.000005896054,0.00004772549,0.000007159732,0.9403082,0.0009145814,0.00000202551,0.001698647],"study_design_scores_gemma":[0.01064065,0.001735762,0.6955179,0.0003005355,0.0001912007,0.000026257,0.0002703455,0.2651816,0.02403916,0.001116215,0.0001395445,0.0008408634],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986595,0.0001244158,0.0005013868,0.0001118089,0.00001413477,0.0003817242,0.00001327763,0.00002380989,0.0001699684],"genre_scores_gemma":[0.9991276,0.000109402,0.0004855387,0.00002815504,0.00001531381,0.00002609326,0.0001277179,0.00002511822,0.00005502061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9162691,"threshold_uncertainty_score":0.5351334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796046398646908,"score_gpt":0.2928683171370167,"score_spread":0.2749078531505476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}