{"id":"W1485413733","doi":"10.1111/ahg.12035","title":"Secondary Analysis of Publicly Available Data Reveals Superoxide and Oxygen Radical Pathways are Enriched for Associations Between Type 2 Diabetes and Low‐Frequency Variants","year":2013,"lang":"en","type":"article","venue":"Annals of Human Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Child and Family Research Institute; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Cancer Institute; National Institutes of Health; Simon Fraser University; Natural Sciences and Engineering Research Council of Canada; Broad Institute","keywords":"Type 2 diabetes; False discovery rate; Missing heritability problem; Heritability; Genome-wide association study; Diabetes mellitus; Genetics; Genetic association; Biology; Locus (genetics); Gene; Computational biology; Bioinformatics; Single-nucleotide polymorphism; Genotype; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003576236,0.0005997502,0.001854525,0.002690754,0.0007175847,0.002025972,0.0005757142,0.0005538521,0.002809752],"category_scores_gemma":[0.007217943,0.0002403141,0.002137442,0.004861114,0.0005968229,0.000578729,0.001388357,0.0007956321,0.001142059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005913216,"about_ca_system_score_gemma":0.001267962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003957334,"about_ca_topic_score_gemma":0.007804992,"domain_scores_codex":[0.9959552,0.0009266321,0.0003538168,0.00170455,0.000572405,0.0004874269],"domain_scores_gemma":[0.9868997,0.006556808,0.003046065,0.00176489,0.001195042,0.0005375649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003081477,0.0004078563,0.8782557,0.001729163,0.003646573,0.0008290266,0.0003713068,0.001215375,0.06190493,0.0007802548,0.01212222,0.03565596],"study_design_scores_gemma":[0.00008206174,0.0001814629,0.9884162,0.00005332277,0.0007022183,0.0003325521,0.0001728759,0.002241851,0.003684591,0.0008235006,0.003284642,0.00002480217],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8877941,0.002439437,0.006658978,0.0007664858,0.00008821982,0.00009458695,0.09900162,0.0013184,0.001838173],"genre_scores_gemma":[0.8813296,0.000593614,0.007452369,0.0003694078,0.00009306182,0.0002146463,0.1089691,0.0002019256,0.0007762606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003957334,"threshold_uncertainty_score":0.01891315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08975566211286656,"score_gpt":0.316776296904358,"score_spread":0.2270206347914914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}