{"id":"W1485642171","doi":"10.1038/mp.2015.84","title":"L-type Ca2+ channel blockade with antihypertensive medication disrupts VTA synaptic plasticity and drug-associated contextual memory","year":2015,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute on Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health","keywords":"Neuroscience; Ventral tegmental area; Glutamatergic; Long-term potentiation; Conditioned place preference; Psychology; NMDA receptor; Addiction; Neuroplasticity; Extinction (optical mineralogy); Synaptic plasticity; Nucleus accumbens; Pharmacology; Glutamate receptor; Medicine; Chemistry; Central nervous system; Dopamine; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001948061,0.0004937911,0.0009979383,0.000316997,0.000475089,0.000676505,0.0008920315,0.0005777466,0.002188254],"category_scores_gemma":[0.0005126843,0.0004501347,0.0005716722,0.0002621823,0.0008787605,0.0008351715,0.0004168138,0.002396233,0.0003019414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009491516,"about_ca_system_score_gemma":0.0009145818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005572934,"about_ca_topic_score_gemma":0.01821488,"domain_scores_codex":[0.9996099,0.00004059928,0.00003838078,0.0000667873,0.00007385126,0.0001704608],"domain_scores_gemma":[0.9996018,0.00004357002,0.0001189894,0.00005299769,0.00002958711,0.0001530583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005862918,0.0008144118,0.001604311,0.00009163929,0.0001259883,0.0002218744,0.00006696627,0.0001732635,0.9836171,0.0002830944,0.0003515249,0.006787005],"study_design_scores_gemma":[0.0008408828,0.008518783,0.1096448,0.00004510772,0.0003953542,0.001149055,0.0003822267,0.006608463,0.8697214,0.0009159337,0.001697088,0.00008112106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978435,0.0002814076,0.0005243332,0.0002205983,0.00009041807,0.00002504305,0.0002583861,0.00005778831,0.0006984915],"genre_scores_gemma":[0.9978623,0.0003976566,0.0004655714,0.0001099775,0.00002902228,0.00003182583,0.0002038275,0.00002539429,0.0008745534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005572934,"threshold_uncertainty_score":0.01108104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03265959001406429,"score_gpt":0.2978866392834277,"score_spread":0.2652270492693634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}