{"id":"W1486067581","doi":"10.1111/j.1365-2036.2011.04590.x","title":"Review article: the design of clinical trials in hepatic encephalopathy - an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement","year":2011,"lang":"en","type":"review","venue":"Alimentary Pharmacology & Therapeutics","topic":"Liver Disease and Transplantation","field":"Medicine","cited_by":349,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Hepatic encephalopathy; Medicine; Cirrhosis; Encephalopathy; Intensive care medicine; Hyperammonemia; Clinical trial; Rifaximin; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09247093,0.002408725,0.008450257,0.005028032,0.001409409,0.006984474,0.00675419,0.01383564,0.005866679],"category_scores_gemma":[0.1908833,0.001074026,0.004907217,0.005338826,0.003729168,0.004650495,0.003369273,0.01119637,0.003709799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007247594,"about_ca_system_score_gemma":0.02946687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002666578,"about_ca_topic_score_gemma":0.003298976,"domain_scores_codex":[0.8889413,0.07169948,0.01955122,0.003775351,0.01472843,0.001304094],"domain_scores_gemma":[0.7845436,0.1453068,0.02156095,0.004736868,0.0387556,0.005096196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00053156,0.0001103254,0.0003383275,0.1233782,0.001044614,0.0001933539,0.000220613,0.0009497438,0.0002390168,0.009172012,0.3229289,0.5408932],"study_design_scores_gemma":[0.001014428,0.0003831261,0.001585102,0.2542295,0.001846102,0.0008189799,0.0001976936,0.0005065243,0.0002756797,0.01668563,0.722334,0.0001233124],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000160148,0.8937175,0.005475695,0.05576536,0.03887882,0.002278806,0.0004759236,0.0000843314,0.003163485],"genre_scores_gemma":[0.003883768,0.8928908,0.01968246,0.04528359,0.02965017,0.005091309,0.0008530327,0.0001168969,0.002548092],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.09247093,"threshold_uncertainty_score":0.4890389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3161130313169462,"score_gpt":0.503374709272029,"score_spread":0.1872616779550828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}