{"id":"W1486205675","doi":"10.1111/apt.13291","title":"Randomised clinical trial: a placebo‐controlled study of intravenous golimumab induction therapy for ulcerative colitis","year":2015,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"UCB Pharma; Janssen Research and Development; Relypsa; Genentech; Norgine; Mitsubishi Tanabe Pharma Corporation; Tillotts Pharma; Shire; Sanofi; Kyowa Hakko Kirin; Janssen Scientific Affairs; Ironwood Pharmaceuticals, Incorporated; Danone; Therakos; Novo Nordisk; Janssen Biotech; Teva Pharmaceutical Industries; Gilead Sciences; Astellas Pharma; Celltrion; Procter and Gamble; Celgene; BioClinica; Pfizer; Biogen; GlaxoSmithKline; Atlantic Healthcare; ActoGeniX; Amgen; IC Design Education Center; Orexigen Therapeutics; Eli Lilly and Company; Bristol-Myers Squibb; Dr. Falk Pharma; Abbott Laboratories","keywords":"Golimumab; Medicine; Placebo; Ulcerative colitis; Internal medicine; Clinical endpoint; Clinical trial; Gastroenterology; Surgery; Tumor necrosis factor alpha; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001479815,0.0002882932,0.000603881,0.00006922667,0.0001067292,0.00001409108,0.0002653267,0.0002187262,0.00004626104],"category_scores_gemma":[0.000005894396,0.0002594694,0.0002752978,0.00006493565,0.0002030364,0.00001063725,0.0000608878,0.0001634914,0.000004087838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005264866,"about_ca_system_score_gemma":0.0003849315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001497882,"about_ca_topic_score_gemma":0.00003385348,"domain_scores_codex":[0.9965553,0.001579282,0.0008860737,0.0004583375,0.0001881707,0.0003328478],"domain_scores_gemma":[0.9985949,0.0001931131,0.0004295903,0.0003066164,0.0002985077,0.0001773089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9469202,0.004378571,0.0005308465,0.000006703543,0.01523653,0.0000180771,0.001150957,0.0001034398,0.02881566,0.000006348964,0.001055669,0.001776962],"study_design_scores_gemma":[0.9510591,0.01559995,0.001876151,0.000002988435,0.004294183,0.000006361989,0.001822226,0.0002137981,0.02215302,0.00008933218,0.002581971,0.0003009413],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873848,0.0003343341,0.0001030205,0.0002048989,0.001927593,0.009891559,0.00004579854,0.00002348866,0.00008450201],"genre_scores_gemma":[0.9927281,0.0003878712,0.0001324134,0.003799723,0.0009923736,0.001665097,0.0001207808,0.0000497007,0.0001239873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01122138,"threshold_uncertainty_score":0.9999858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07750055535918386,"score_gpt":0.3899949360759915,"score_spread":0.3124943807168076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}