{"id":"W1486205675","doi":"10.1111/apt.13291","title":"Randomised clinical trial: a placebo‐controlled study of intravenous golimumab induction therapy for ulcerative colitis","year":2015,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"UCB Pharma; Janssen Research and Development; Relypsa; Genentech; Norgine; Mitsubishi Tanabe Pharma Corporation; Tillotts Pharma; Shire; Sanofi; Kyowa Hakko Kirin; Janssen Scientific Affairs; Ironwood Pharmaceuticals, Incorporated; Danone; Therakos; Novo Nordisk; Janssen Biotech; Teva Pharmaceutical Industries; Gilead Sciences; Astellas Pharma; Celltrion; Procter and Gamble; Celgene; BioClinica; Pfizer; Biogen; GlaxoSmithKline; Atlantic Healthcare; ActoGeniX; Amgen; IC Design Education Center; Orexigen Therapeutics; Eli Lilly and Company; Bristol-Myers Squibb; Dr. Falk Pharma; Abbott Laboratories","keywords":"Golimumab; Medicine; Placebo; Ulcerative colitis; Internal medicine; Clinical endpoint; Clinical trial; Gastroenterology; Surgery; Tumor necrosis factor alpha; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007017226,0.002805468,0.007441322,0.0009163666,0.0009309,0.001904862,0.002054682,0.004435222,0.01944642],"category_scores_gemma":[0.008893007,0.001229802,0.002368435,0.0009563035,0.003226701,0.00189861,0.001067705,0.005219162,0.003326561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001046072,"about_ca_system_score_gemma":0.002717407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009235198,"about_ca_topic_score_gemma":0.001123063,"domain_scores_codex":[0.9955176,0.002813325,0.0003105693,0.0006503207,0.0003391517,0.0003691027],"domain_scores_gemma":[0.9954737,0.001670454,0.0009203087,0.000573151,0.0003647926,0.0009976656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9936497,0.00204398,0.00006620408,0.000440274,0.0002146682,0.00001960142,0.00002040298,0.00005955268,0.0005657137,0.00008333021,0.0003116593,0.002525051],"study_design_scores_gemma":[0.9905814,0.008880575,0.0001099629,0.0000156677,0.00006266296,0.000005426309,0.000002943994,0.0000514771,0.00002942115,0.00003749989,0.0002189798,0.000003941566],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8342614,0.01929914,0.005065839,0.006173236,0.01200706,0.1071317,0.005816214,0.0007457864,0.009499763],"genre_scores_gemma":[0.8433529,0.008729138,0.009308519,0.007657694,0.004583922,0.1097664,0.003677676,0.0001049965,0.01281882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01944642,"threshold_uncertainty_score":0.06505477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07750055535918386,"score_gpt":0.3899949360759915,"score_spread":0.3124943807168076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}