{"id":"W1486784775","doi":"10.1023/a:1025568714217","title":"Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and suceptibility to a mitochondrial toxin","year":2003,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Glycogenolysis; Phosphodiesterase; Gluconeogenesis; Hepatocyte; Chemistry; Toxin; Phosphodiesterase inhibitor; Pharmacology; Internal medicine; Endocrinology; Cell biology; Biochemistry; Biology; Enzyme; In vitro; Metabolism; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000145226,0.0003192122,0.0002841826,0.00005322226,0.00009876749,0.0000317037,0.00009165143,0.0002712103,0.00001116376],"category_scores_gemma":[0.0002161847,0.0003137367,0.00013678,0.0001371354,0.0001339909,0.000004393876,0.00008980701,0.00009026066,0.000003059853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002717653,"about_ca_system_score_gemma":0.00006813397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001893152,"about_ca_topic_score_gemma":0.000003407927,"domain_scores_codex":[0.9983602,0.0001146294,0.0003104176,0.0006957915,0.0002092772,0.0003097111],"domain_scores_gemma":[0.9990635,0.00002637009,0.0001035798,0.0004364978,0.00008329995,0.0002867565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002585657,0.000138534,0.0007535365,0.0001701901,0.0000836265,0.00002207907,0.00004567029,0.00001336102,0.9974264,0.00005189761,0.0001008795,0.0009352757],"study_design_scores_gemma":[0.001165724,0.0002999159,0.0002703855,0.00005124797,0.00006987674,0.00002325795,0.00005948878,0.000005828668,0.9960047,0.00003648671,0.00167167,0.0003414181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929845,0.003494327,0.002663204,0.0000512298,0.0001922182,0.0003796487,0.00002534575,0.00001424958,0.0001952224],"genre_scores_gemma":[0.9985726,0.00004031366,0.000640541,0.0003091159,0.00007047538,0.00003973235,0.0000697942,0.00003173188,0.0002256427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005588097,"threshold_uncertainty_score":0.9999315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004123523159658929,"score_gpt":0.2008206726322661,"score_spread":0.1966971494726071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}