{"id":"W1486948662","doi":"10.1038/74279","title":"The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development","year":2000,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Biology; Cell biology; Protein tyrosine phosphatase; Fibroblast growth factor; Limb bud; Receptor tyrosine kinase; Limb development; Mesoderm; Apical ectodermal ridge; Mutant; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Ectoderm; Morphogenesis; SH2 domain; Genetics; Receptor; Embryonic stem cell; Gene; Embryo; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001298151,0.0005096346,0.0002423719,0.0003663721,0.000408472,0.0005989659,0.0003235395,0.0005014297,0.001304119],"category_scores_gemma":[0.0002060367,0.0004274647,0.0002165577,0.0002127185,0.0004605076,0.000358381,0.0005469196,0.0007997387,0.0007608569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005736336,"about_ca_system_score_gemma":0.0003234677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001303471,"about_ca_topic_score_gemma":0.003158896,"domain_scores_codex":[0.9998325,0.00001272415,0.00001083227,0.00003323375,0.00008014885,0.00003054072],"domain_scores_gemma":[0.999837,0.00002581642,0.00004416124,0.00001819051,0.00001753028,0.00005721814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006209656,0.000004401036,0.0002240172,0.00002294982,0.000003821867,0.0001618847,0.000006660181,0.000101178,0.9976835,0.000299346,0.0001146253,0.001315561],"study_design_scores_gemma":[0.00002157398,0.00003422068,0.01060185,0.000005949361,0.0000181595,0.001124101,0.00003124421,0.001877787,0.9768891,0.0004040328,0.008982861,0.000009199817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960582,0.006108623,0.02177107,0.0007232564,0.0001936775,0.00004660854,0.001480906,0.000687818,0.008406132],"genre_scores_gemma":[0.9878362,0.001347135,0.003644192,0.000112077,0.00003210866,0.00002268794,0.001074112,0.0001199258,0.005811521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001304119,"threshold_uncertainty_score":0.004362702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008913320145284351,"score_gpt":0.258833816599193,"score_spread":0.2499204964539087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}