{"id":"W1486948662","doi":"10.1038/74279","title":"The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development","year":2000,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Biology; Cell biology; Protein tyrosine phosphatase; Fibroblast growth factor; Limb bud; Receptor tyrosine kinase; Limb development; Mesoderm; Apical ectodermal ridge; Mutant; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Ectoderm; Morphogenesis; SH2 domain; Genetics; Receptor; Embryonic stem cell; Gene; Embryo; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002279386,0.0002787763,0.0001545009,0.00002055529,0.0003826709,0.00008407554,0.0005716137,0.0004352532,0.00009346042],"category_scores_gemma":[0.0001067028,0.0002203572,0.0001128936,0.0001222734,0.0001157651,0.000003921355,0.0001212697,0.0002005581,0.00004717502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002771921,"about_ca_system_score_gemma":0.0001774551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003082567,"about_ca_topic_score_gemma":0.00003076178,"domain_scores_codex":[0.9983958,0.0000275226,0.0003200214,0.0005077843,0.0002421748,0.0005066968],"domain_scores_gemma":[0.9988378,0.00002646237,0.00008875185,0.0007597773,0.0001519281,0.0001353391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001771942,0.0002237188,0.0009332605,0.00009673598,0.0002671886,0.00001279215,0.0001229411,0.00007789892,0.04912369,0.001303556,0.4552727,0.4907936],"study_design_scores_gemma":[0.0003847582,0.0001454143,0.0005498,0.000006773615,0.00001498131,0.000005410475,0.000005112505,0.00001590529,0.5002214,0.0001132817,0.4983708,0.0001664072],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3351865,0.6529747,0.00130889,0.004010465,0.001233359,0.002599807,0.001617201,0.00009222142,0.0009768475],"genre_scores_gemma":[0.9443268,0.005226394,0.03122727,0.005451696,0.001069972,0.0003323582,0.002160059,0.0001204531,0.01008501],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6477483,"threshold_uncertainty_score":0.8985906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008913320145284351,"score_gpt":0.258833816599193,"score_spread":0.2499204964539087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}