{"id":"W1487322990","doi":"10.1016/j.immuni.2015.07.003","title":"Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation","year":2015,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":135,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; National Research Foundation of Korea; Korea Research Institute of Bioscience and Biotechnology; Ministry of Education; Ministry of Science, ICT and Future Planning; Hanyang University","keywords":"Inflammation; Biology; Cell biology; Sirtuin; Nuclear receptor; Transcription factor; Receptor; Sirtuin 1; Regulator; Mitochondrial biogenesis; Signal transduction; Downregulation and upregulation; NAD+ kinase; Immunology; Function (biology); Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003827678,0.0005978348,0.0004520486,0.0005027602,0.0003699553,0.0006161509,0.000369775,0.0004582926,0.003884384],"category_scores_gemma":[0.000332939,0.0003447768,0.0005973132,0.0002020476,0.0005186611,0.0004984598,0.0005893192,0.0008577409,0.001711434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004267317,"about_ca_system_score_gemma":0.000319526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000447847,"about_ca_topic_score_gemma":0.0008836691,"domain_scores_codex":[0.9994808,0.0001028265,0.00003450099,0.00009275527,0.00009534509,0.0001937486],"domain_scores_gemma":[0.9997521,0.00002291489,0.00008532082,0.00003795992,0.00004150764,0.00006017703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008086135,0.00003470865,0.0007393843,0.00005422478,0.00001447394,0.0001634388,0.00002533737,0.00008214907,0.9951925,0.0004565355,0.0001927996,0.00223583],"study_design_scores_gemma":[0.0002005095,0.0005175743,0.03582163,0.00005990451,0.00008802967,0.001304037,0.0004541076,0.002582198,0.9403154,0.001071563,0.01755269,0.00003236708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770287,0.006165498,0.007544274,0.0007897664,0.0002962133,0.00004110128,0.001065108,0.0002683411,0.006800951],"genre_scores_gemma":[0.9857187,0.002114197,0.002805303,0.0002787708,0.00006806717,0.00003422684,0.0009173754,0.000103227,0.007960112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003884384,"threshold_uncertainty_score":0.01299453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388955111000435,"score_gpt":0.2522060438537986,"score_spread":0.2283164927437942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}