{"id":"W1487472693","doi":"10.1111/bph.12847","title":"Glutathione administration reduces mitochondrial damage and shifts cell death from necrosis to apoptosis in ageing diabetic mice hearts during exercise","year":2014,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Glutathione; Programmed cell death; GCLC; Oxidative stress; Necrosis; Apoptosis; In vivo; Reactive oxygen species; Pharmacology; Endocrinology; Internal medicine; Medicine; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002671973,0.0001561607,0.0003318797,0.0001148095,0.00009460479,0.00006067043,0.0002267426,0.0001896058,0.00003545307],"category_scores_gemma":[0.0001104791,0.0001959714,0.00006735915,0.00008480507,0.00007718278,0.00001723505,0.0001378626,0.0002512721,0.000003115174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002979958,"about_ca_system_score_gemma":0.0000649979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009647515,"about_ca_topic_score_gemma":0.00008420573,"domain_scores_codex":[0.9984689,0.0002963839,0.0004831912,0.0003366451,0.0001066903,0.0003082045],"domain_scores_gemma":[0.999372,0.00007968723,0.0002213953,0.00007560915,0.00008764201,0.0001636498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005392215,0.0001246898,0.000873002,0.00001581071,0.00003009917,0.0001104902,0.00009368778,0.00005697003,0.9930873,4.853958e-7,0.0009931835,0.00407509],"study_design_scores_gemma":[0.00262063,0.000503663,0.0302896,0.00009953515,0.00007253396,0.0002267597,0.00003841172,0.00003785707,0.9648034,0.00007613198,0.001021195,0.0002102828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969059,0.001162248,0.0001508777,0.0003970659,0.001091727,0.0002234309,0.00001783829,0.000005627401,0.00004534726],"genre_scores_gemma":[0.9935165,0.0007994095,0.004262793,0.0004129668,0.0009134687,0.00002038748,0.00002192092,0.00002248689,0.00003006804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02941659,"threshold_uncertainty_score":0.799148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008407645100304655,"score_gpt":0.2576502470282959,"score_spread":0.2492426019279912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}