{"id":"W1487486460","doi":"","title":"NON-VIRAL GENE DELIVERY WITH pH-SENSITIVE GEMINI NANOPARTICLES: SYNTHESIS OF GEMINI SURFACTANT BUILDING BLOCKS, CHARACTERIZATION AND IN VITRO SCREENING OF TRANSFECTION EFFICIENCY AND TOXICITY","year":2008,"lang":"en","type":"article","venue":"University Library - University of Saskatchewan (University of Saskatchewan)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Brookhaven National Laboratory; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gene delivery; Transfection; Pulmonary surfactant; Chemistry; In vitro; Toxicity; Nanoparticle; Nanotechnology; Biochemistry; Gene; Materials science; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000592123,0.0003622213,0.0002867863,0.0002361349,0.0001711702,0.0002711386,0.0002430136,0.0003739247,0.0003065185],"category_scores_gemma":[0.0004073468,0.0002464196,0.0002501982,0.0002550361,0.0002143414,0.000323331,0.0001778131,0.0004029636,0.0002179626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000536064,"about_ca_system_score_gemma":0.0003550082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001146993,"about_ca_topic_score_gemma":0.002536847,"domain_scores_codex":[0.9997486,0.00005841745,0.00003114843,0.00004355099,0.00008349388,0.00003477517],"domain_scores_gemma":[0.9998135,0.00004311658,0.0000549463,0.00002464325,0.00004201693,0.00002178712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004006481,0.000008609561,0.00004654457,0.00001709429,0.000002580591,0.00001314355,0.00001138167,0.00005505961,0.9990301,0.00005130818,0.000009201383,0.0007148882],"study_design_scores_gemma":[0.000002082297,0.00004236567,0.0001592533,6.329507e-7,0.000002953328,0.00003357657,0.000002107873,0.0002369911,0.9992256,0.000006740164,0.0002863969,0.000001274086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716929,0.002096981,0.02461869,0.00008729289,0.00001639525,0.0001423038,0.000193256,0.0001657792,0.0009864822],"genre_scores_gemma":[0.972859,0.001375731,0.02232157,0.00004448638,0.000005135998,0.00007788683,0.0004101286,0.00006349995,0.002842674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146993,"threshold_uncertainty_score":0.003889501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004859449783810621,"score_gpt":0.1515886562865083,"score_spread":0.1467292065026977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}