{"id":"W1487730160","doi":"10.4049/jimmunol.179.8.5137","title":"<i>Mycobacterium bovis</i> Bacillus Calmette-Guerin Secreting Active Cathepsin S Stimulates Expression of Mature MHC Class II Molecules and Antigen Presentation in Human Macrophages","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Genentech; Michael Smith Health Research BC; British Columbia Lung Association","keywords":"MHC class II; Antigen presentation; Microbiology; Biology; MHC class I; Antigen processing; Mycobacterium bovis; Cathepsin S; Antigen; Phagosome; Secretion; T cell; Mycobacterium tuberculosis; Cathepsin L; Major histocompatibility complex; Cathepsin; Immunology; Immune system; Tuberculosis; Phagocytosis; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00121882,0.0001759416,0.0003949013,0.0003065735,0.0002232357,0.000008341504,0.0002610765,0.0003085178,0.00005643634],"category_scores_gemma":[0.0001594256,0.0001130499,0.00007450156,0.0001515889,0.00034207,0.0002105596,0.000169488,0.0006139532,0.000003884599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004906773,"about_ca_system_score_gemma":0.00004291183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000115475,"about_ca_topic_score_gemma":0.00001679388,"domain_scores_codex":[0.99804,0.0007307564,0.0007460046,0.0001178657,0.00006023573,0.0003051144],"domain_scores_gemma":[0.9983882,0.0004218708,0.0008115167,0.0001965438,0.0001686613,0.00001321859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003078326,0.00006880956,0.0007939594,0.00001936422,0.0001352051,0.00001674081,0.004901388,0.0000501399,0.9869053,0.00004647947,0.00007547126,0.003908788],"study_design_scores_gemma":[0.001553394,0.0005905451,0.07941462,0.0001335537,0.00004084488,0.0004124208,0.002271585,0.000004627393,0.914247,0.0001146508,0.001111906,0.0001048678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909599,0.007903012,0.0002637756,0.0002923756,0.0002886195,0.0001764071,0.000006325884,0.000009276292,0.0001002441],"genre_scores_gemma":[0.9986139,0.001033767,0.00009152233,0.00003602093,0.00003096195,0.000001351916,0.00002151627,0.00001520239,0.0001557721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07862066,"threshold_uncertainty_score":0.461004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007039334085842811,"score_gpt":0.2508256958215871,"score_spread":0.2437863617357443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}