{"id":"W1487730160","doi":"10.4049/jimmunol.179.8.5137","title":"<i>Mycobacterium bovis</i> Bacillus Calmette-Guerin Secreting Active Cathepsin S Stimulates Expression of Mature MHC Class II Molecules and Antigen Presentation in Human Macrophages","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Genentech; Michael Smith Health Research BC; British Columbia Lung Association","keywords":"MHC class II; Antigen presentation; Microbiology; Biology; MHC class I; Antigen processing; Mycobacterium bovis; Cathepsin S; Antigen; Phagosome; Secretion; T cell; Mycobacterium tuberculosis; Cathepsin L; Major histocompatibility complex; Cathepsin; Immunology; Immune system; Tuberculosis; Phagocytosis; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113141,0.0002616065,0.0002443886,0.00009715079,0.0000798299,0.0002194831,0.00007790751,0.000196684,0.0007222326],"category_scores_gemma":[0.0001065796,0.00008594687,0.0001868374,0.00008414138,0.0001532704,0.00007927906,0.0001642523,0.0003159489,0.0003805771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001863606,"about_ca_system_score_gemma":0.0001377816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005205609,"about_ca_topic_score_gemma":0.0005575906,"domain_scores_codex":[0.9998974,0.00002541582,0.000009568654,0.0000138706,0.0000182697,0.00003560276],"domain_scores_gemma":[0.9999478,0.000009685056,0.00001409154,0.000008278224,0.000006927574,0.00001327325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002057473,0.00004510557,0.0002553434,0.00002875853,0.000003099429,0.00003915321,0.0000100992,0.00002409748,0.998309,0.00001669675,0.00004905605,0.001013763],"study_design_scores_gemma":[0.00006044911,0.001800136,0.008750515,0.00001134203,0.0000178755,0.0005915418,0.00003293881,0.0005749539,0.9851371,0.00003391916,0.002985356,0.000003883475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970578,0.001329171,0.000419575,0.00007570464,0.00002217149,0.000020523,0.00008435505,0.00004783939,0.0009428224],"genre_scores_gemma":[0.9974892,0.0004485004,0.0006460854,0.0000569049,0.00001812684,0.00001849919,0.0002872548,0.00001037782,0.001025161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007222326,"threshold_uncertainty_score":0.002416074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007039334085842811,"score_gpt":0.2508256958215871,"score_spread":0.2437863617357443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}