{"id":"W1488266902","doi":"10.1113/jphysiol.2012.243576","title":"Ca<sup>2+</sup> sensitization due to myosin light chain phosphatase inhibition and cytoskeletal reorganization in the myogenic response of skeletal muscle resistance arteries","year":2012,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Libin Cardiovascular Institute of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Myogenic contraction; Myosin-light-chain phosphatase; Rho-associated protein kinase; Vasoconstriction; Myosin light-chain kinase; Myosin; Skeletal muscle; Cell biology; RHOA; Cytoskeleton; Arteriole; Biology; Vascular smooth muscle; Phosphorylation; Anatomy; Endocrinology; Biochemistry; Circulatory system; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001641489,0.0001050304,0.0002777061,0.0001337089,0.00006288387,0.000004633368,0.00006412097,0.00006379944,0.00002334351],"category_scores_gemma":[0.0005816358,0.00006183608,0.00004574124,0.0003396127,0.00008798452,0.0001406904,0.00002704911,0.0001762518,0.000008184755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003893684,"about_ca_system_score_gemma":0.00004471823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001359407,"about_ca_topic_score_gemma":0.000007237953,"domain_scores_codex":[0.998369,0.0008530867,0.0003522655,0.00007530485,0.000165358,0.0001849381],"domain_scores_gemma":[0.9988878,0.0005255946,0.000223797,0.0001797058,0.0001208472,0.00006224548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002733249,0.0001205078,0.0001449425,0.00006775971,0.00002425541,0.00001911126,0.008705874,0.0001765022,0.986575,0.0001872951,0.0009672794,0.0002782446],"study_design_scores_gemma":[0.004804576,0.002608567,0.4816996,0.0005827381,0.0004040829,0.001752903,0.005192465,0.0004296484,0.4983577,0.001599114,0.002260851,0.0003077125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943017,0.000873549,0.0002347374,0.004278219,0.00005922032,0.0002218579,0.000009065979,0.000003886704,0.00001770094],"genre_scores_gemma":[0.9986159,0.0001106226,0.0001356733,0.0007531999,0.000324851,0.000002326687,0.0000112936,0.00001307725,0.00003308985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4882173,"threshold_uncertainty_score":0.2521602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006554030769379163,"score_gpt":0.2328331507675215,"score_spread":0.2262791199981423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}