{"id":"W1489032582","doi":"10.1016/s0076-6879(03)68005-5","title":"Use of Limited Proteolysis to Identify Protein Domains Suitable for Structural Analysis","year":2003,"lang":"en","type":"article","venue":"Methods in enzymology on CD-ROM/Methods in enzymology","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Proteolysis; Computational biology; Chemistry; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00628748,0.0007127557,0.002136787,0.001911071,0.0001907789,0.00003854058,0.0009677006,0.001334989,0.0004905316],"category_scores_gemma":[0.009530178,0.0007407052,0.0005556582,0.003454288,0.0004896259,0.0001822278,0.0002900233,0.001258898,0.00000439225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004325343,"about_ca_system_score_gemma":0.0001310735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004122467,"about_ca_topic_score_gemma":0.00065271,"domain_scores_codex":[0.9906338,0.004006954,0.002025983,0.001744285,0.0002428197,0.001346116],"domain_scores_gemma":[0.990977,0.005749994,0.0008375646,0.001918698,0.0002922117,0.0002244902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004299638,0.0003509146,0.007369999,0.0001343134,0.0003822386,0.00002285806,0.0003298273,0.004048472,0.9339036,0.04056356,0.00004679888,0.01241747],"study_design_scores_gemma":[0.001259043,0.0003773239,0.00757703,0.00006607095,0.0003262338,0.00004781097,0.0001591319,0.0007699758,0.8461338,0.1363655,0.006099016,0.0008191324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4371945,0.0001028486,0.5601906,0.000140453,0.0001000541,0.001641955,0.00009166628,0.0001059785,0.0004319376],"genre_scores_gemma":[0.1014813,0.00002362208,0.8917578,0.0002767475,0.00004598445,0.00539249,0.00006333432,0.0001049569,0.0008537003],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.3357131,"threshold_uncertainty_score":0.9999615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07309565393278183,"score_gpt":0.4578323905659326,"score_spread":0.3847367366331508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}