{"id":"W1489081786","doi":"10.1016/j.yjmcc.2015.05.009","title":"Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4","year":2015,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Heart rate and cardiovascular health","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Ivabradine; hERG; Repolarization; Torsades de pointes; Medicine; Cardiology; Pharmacology; Internal medicine; QT interval; Heart rate; Electrophysiology; Potassium channel","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001666007,0.0004252963,0.0005085131,0.0001590653,0.0001645969,0.0003688652,0.0003635717,0.0004124887,0.003312462],"category_scores_gemma":[0.0004938007,0.000172592,0.0002500258,0.00009954418,0.0002661272,0.0002826607,0.0001130077,0.001405846,0.000533862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003702019,"about_ca_system_score_gemma":0.0002896357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008880359,"about_ca_topic_score_gemma":0.001563544,"domain_scores_codex":[0.9998765,0.00003104991,0.000008177046,0.00001827608,0.00001294314,0.0000529179],"domain_scores_gemma":[0.9998703,0.00003689608,0.00003258509,0.00001321511,0.00001014736,0.00003690861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007302432,0.0006346866,0.000557868,0.0001890218,0.00004937022,0.0001427778,0.00009025999,0.0003438533,0.9643893,0.0004167754,0.0009610894,0.02492265],"study_design_scores_gemma":[0.008465431,0.04385925,0.04127337,0.0001011762,0.0001852836,0.002312651,0.0002131368,0.00374962,0.8772516,0.0006176188,0.0219014,0.00006932552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882182,0.003780623,0.001806519,0.0003204044,0.0001898433,0.0001246003,0.000316978,0.0002546059,0.004988088],"genre_scores_gemma":[0.9955392,0.001180425,0.0009543218,0.0001283886,0.00006346621,0.00004208264,0.000278138,0.00002324487,0.00179055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003312462,"threshold_uncertainty_score":0.01108134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02866367537524315,"score_gpt":0.2895417063733142,"score_spread":0.260878030998071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}