{"id":"W1489149646","doi":"10.1212/wnl.84.14_supplement.p7.243","title":"Sustained Low Rate of Brain Volume Loss under Long-term Delayed-Release Dimethyl Fumarate Treatment in Relapsing-Remitting Multiple Sclerosis Patients: Results from the ENDORSE Study (P7.243)","year":2015,"lang":"en","type":"article","venue":"Neurology","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Dimethyl fumarate; Multiple sclerosis; Relapsing remitting; Medicine; Term (time); Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002964504,0.0004432943,0.001341339,0.0002139993,0.0002261013,0.0005166419,0.0003266254,0.0005315955,0.001028146],"category_scores_gemma":[0.002276483,0.0002336735,0.0008746448,0.0002529971,0.0003253359,0.0005136453,0.0002849517,0.0008122474,0.0001855864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608892,"about_ca_system_score_gemma":0.0003268668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006057128,"about_ca_topic_score_gemma":0.001232805,"domain_scores_codex":[0.999014,0.0005489951,0.00006317006,0.0001420463,0.0001592563,0.00007261135],"domain_scores_gemma":[0.998031,0.0005431485,0.0006472141,0.0002873464,0.0001875635,0.0003037197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5765567,0.007624304,0.2971773,0.0006768058,0.005388528,0.0003442147,0.0004654321,0.0008577353,0.02886862,0.0000844003,0.001235045,0.08072093],"study_design_scores_gemma":[0.04539895,0.1737332,0.7697068,0.00003365577,0.002532892,0.0007117887,0.0001894144,0.0007632751,0.005153867,0.00007002666,0.001655771,0.00005037788],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998847,0.0005731017,0.00005095877,0.00002868742,0.000005132997,0.00004066424,0.0002622754,0.000006455251,0.0001855979],"genre_scores_gemma":[0.998939,0.0001953538,0.0001350596,0.00004624112,0.00002313736,0.00004309785,0.0004447184,0.000003102219,0.0001702775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002964504,"threshold_uncertainty_score":0.01567805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05565992409277024,"score_gpt":0.2671751607322099,"score_spread":0.2115152366394397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}