{"id":"W1490058918","doi":"10.1158/1538-7445.am2014-2914","title":"Abstract 2914: Phosphoproteomic and transcriptional biomarkers predict response to SAR302503, a JAK2 inhibitor, in human acute myeloid leukemia preclinical models","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Myeloid leukemia; Biomarker; Cancer research; NPM1; Leukemia; Medicine; Cancer; Myeloid; Biomarker discovery; Oncology; Biology; Immunology; Internal medicine; Gene; Proteomics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002883677,0.0004361219,0.0004318482,0.0004132477,0.0001322947,0.0003729794,0.0001845224,0.0003458201,0.002340038],"category_scores_gemma":[0.0002129568,0.0001783102,0.0003449059,0.0002849447,0.0001707451,0.0001744698,0.0001590764,0.0006670296,0.0005006412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003795562,"about_ca_system_score_gemma":0.0003232925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009499445,"about_ca_topic_score_gemma":0.001299918,"domain_scores_codex":[0.9998434,0.00001699901,0.00001087596,0.00003903392,0.00005982236,0.00002989406],"domain_scores_gemma":[0.9998801,0.00001820177,0.00004014796,0.000008567622,0.00002190128,0.00003099788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001992226,0.0005794369,0.00619236,0.00005367459,0.000040097,0.00003831859,0.00001600765,0.001660431,0.9822442,0.00004733335,0.0005757436,0.006560257],"study_design_scores_gemma":[0.0003082205,0.007006786,0.1002462,0.000009374707,0.0001331892,0.0003630218,0.00007312224,0.01710896,0.8719381,0.0001419419,0.002645189,0.00002597579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907371,0.0008464735,0.002260598,0.0001286194,0.00002701327,0.000140714,0.004815127,0.0001479967,0.0008963106],"genre_scores_gemma":[0.9896668,0.0003731313,0.002373963,0.0001195605,0.000008828621,0.0001712847,0.005823821,0.00002691395,0.001435658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002340038,"threshold_uncertainty_score":0.007828236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07934854208616081,"score_gpt":0.4099494661520082,"score_spread":0.3306009240658474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}