{"id":"W1491831470","doi":"10.1186/s13630-015-0016-y","title":"The primary cilium functions as a mechanical and calcium signaling nexus","year":2015,"lang":"en","type":"article","venue":"Cilia","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; National Science Foundation","keywords":"Cilium; Mechanotransduction; Cell biology; TRPV4; Mechanosensation; Osteocyte; Biology; Transient receptor potential channel; Calcium signaling; Intraflagellar transport; Chemistry; Intracellular; Biophysics; Ion channel; Receptor; Biochemistry; Osteoblast","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555055,0.00008772354,0.00006879915,0.000008494723,0.0001281418,0.00003308019,0.0000972175,0.00007426651,0.000009864852],"category_scores_gemma":[0.0002298078,0.0000642181,0.00004348705,0.00003743855,0.00008043193,0.000001525041,0.0001048579,0.00005021943,0.00003777259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009039039,"about_ca_system_score_gemma":0.0002090853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001498262,"about_ca_topic_score_gemma":0.000005411355,"domain_scores_codex":[0.9993716,0.00004127931,0.0001120822,0.0002018848,0.0001062008,0.0001669234],"domain_scores_gemma":[0.9994212,0.00001432132,0.00002573034,0.000228134,0.00007468672,0.0002358608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003225624,0.00008843603,0.0008864652,0.0000209204,0.00009885366,0.00000971313,0.00009065286,0.00004991933,0.8931494,0.0003452084,0.1012754,0.003662539],"study_design_scores_gemma":[0.001784623,0.0008996789,0.003674925,0.0000175891,0.0001428604,0.0000994744,0.001644021,0.0002345774,0.1570015,0.004512494,0.8294985,0.0004897325],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791486,0.005921709,0.003324811,0.0009941901,0.0005366413,0.0002085672,0.00002854383,0.00002617281,0.009810712],"genre_scores_gemma":[0.9946622,0.00004122798,0.0001254612,0.0006841457,0.0002302701,0.0000215939,0.00004919669,0.00001041746,0.004175473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7361478,"threshold_uncertainty_score":0.2618738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978029999294317,"score_gpt":0.2505637071915281,"score_spread":0.2307834071985849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}