{"id":"W1492057828","doi":"10.1111/j.1471-4159.2010.06846.x","title":"Distinct biochemical signatures characterize peripherin isoform expression in both traumatic neuronal injury and motor neuron disease","year":2010,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Centre hospitalier de l'Université Laval; Occupational Cancer Research Centre; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; ALS Society of Canada","keywords":"Peripherin; Gene isoform; Amyotrophic lateral sclerosis; Motor neuron; Biology; Intermediate filament; Intermediate Filament Protein; Cell biology; Genetically modified mouse; Neuroscience; Transgene; Pathology; Disease; Genetics; Gene; Medicine; Cell; Spinal cord; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176627,0.0001741497,0.0001666312,0.0005717946,0.0001288652,0.0002438838,0.00008699307,0.000210505,0.000604544],"category_scores_gemma":[0.0002969511,0.0001185017,0.0001065271,0.0002284403,0.0002158753,0.0001799496,0.0002179009,0.0002054249,0.0001509806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008632956,"about_ca_system_score_gemma":0.00006631343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001579079,"about_ca_topic_score_gemma":0.0003216956,"domain_scores_codex":[0.9999106,0.00001297509,0.00001202668,0.00002348808,0.0000260525,0.00001474678],"domain_scores_gemma":[0.9997798,0.00002100183,0.0001123081,0.00001288289,0.00002593526,0.00004809665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004768801,0.00003051322,0.01512349,0.00003410606,0.00001968562,0.0004447695,0.00009185567,0.00003379346,0.9811709,0.00005721072,0.00002024262,0.002496653],"study_design_scores_gemma":[0.00001672577,0.0006541965,0.9141525,0.0000138655,0.00004322864,0.008459206,0.0002310613,0.0003131696,0.07518736,0.0002052338,0.0007114678,0.00001199148],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988359,0.0003428261,0.0003336588,0.000009461102,0.000001513734,0.000004088046,0.00006497285,0.000007451885,0.0004000658],"genre_scores_gemma":[0.9967927,0.0006029215,0.001161112,0.00003111043,0.000008559612,0.00001583726,0.0004484414,0.000007792947,0.0009314768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000604544,"threshold_uncertainty_score":0.002022386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01433860592591431,"score_gpt":0.276218798815008,"score_spread":0.2618801928890937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}