{"id":"W1492214690","doi":"10.1186/ar1781","title":"Histone deacetylases--a new target for suppression of cartilage degradation?","year":2005,"lang":"en","type":"letter","venue":"Arthritis Research & Therapy","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"","keywords":"Aggrecan; Oncostatin M; ADAMTS; Matrix metalloproteinase; Trichostatin A; Metalloproteinase; Cartilage; Cancer research; Chemistry; Histone deacetylase; Cell biology; Thrombospondin; Histone; Medicine; Immunology; Biochemistry; Inflammation; Biology; Osteoarthritis; Interleukin 6; Pathology; Anatomy; Articular cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006307987,0.0005918677,0.0008358844,0.0002348123,0.0003156017,0.0007133207,0.000566075,0.00413802,0.003146718],"category_scores_gemma":[0.0005074213,0.0002097663,0.0004717498,0.0002256927,0.001074597,0.001724911,0.0003540156,0.00361046,0.002534218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009434044,"about_ca_system_score_gemma":0.0003729892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002190881,"about_ca_topic_score_gemma":0.0006962715,"domain_scores_codex":[0.9997568,0.00004823316,0.00002511158,0.00004653327,0.00008578382,0.0000374721],"domain_scores_gemma":[0.9998178,0.0000697936,0.00002642697,0.00002312584,0.00002914578,0.00003363206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001990761,0.0005584421,0.003034675,0.00298438,0.0002969332,0.01620914,0.0003569965,0.0005254856,0.09797815,0.04607549,0.3548664,0.4751231],"study_design_scores_gemma":[0.0007388355,0.000821289,0.001411486,0.000209585,0.00006784039,0.01309203,0.0002041326,0.0004939993,0.01668688,0.01436422,0.9518669,0.00004282551],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.01317391,0.5695482,0.005102734,0.3750884,0.02165718,0.0001050679,0.0001774466,0.0002392558,0.01490783],"genre_scores_gemma":[0.1662766,0.4816581,0.006518858,0.2511637,0.04726241,0.0002994011,0.0002656836,0.000079362,0.04647602],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.00413802,"threshold_uncertainty_score":0.01052678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04246406934857222,"score_gpt":0.3646480608111223,"score_spread":0.3221839914625501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}