{"id":"W1492214690","doi":"10.1186/ar1781","title":"Histone deacetylases--a new target for suppression of cartilage degradation?","year":2005,"lang":"en","type":"letter","venue":"Arthritis Research & Therapy","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"","keywords":"Aggrecan; Oncostatin M; ADAMTS; Matrix metalloproteinase; Trichostatin A; Metalloproteinase; Cartilage; Cancer research; Chemistry; Histone deacetylase; Cell biology; Thrombospondin; Histone; Medicine; Immunology; Biochemistry; Inflammation; Biology; Osteoarthritis; Interleukin 6; Pathology; Anatomy; Articular cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001329951,0.0004540274,0.0006247617,0.0004836491,0.0003337013,0.00008050061,0.0009468559,0.001211776,0.000517894],"category_scores_gemma":[0.0005450278,0.0004580348,0.0004533142,0.0003405495,0.0005754678,0.00001808834,0.0002295346,0.001514014,0.00006967958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001742193,"about_ca_system_score_gemma":0.001394641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002748942,"about_ca_topic_score_gemma":0.0001753746,"domain_scores_codex":[0.9945852,0.0007787475,0.0006983792,0.001085663,0.001552617,0.001299389],"domain_scores_gemma":[0.996896,0.0002684885,0.0002060718,0.001357114,0.0009980679,0.0002742765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002839221,0.00007347149,0.000007284409,0.00004440656,0.00004712732,0.00002813828,0.00005381359,0.000006066951,0.3536658,0.000005042054,0.6171783,0.02860672],"study_design_scores_gemma":[0.001407609,0.0009882587,0.000002566243,0.0000960148,0.000002465082,0.00001446483,0.00001140651,0.000007741713,0.4389345,0.00007402083,0.5582262,0.0002347245],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.3587167,0.1452781,0.00308456,0.4751439,0.001443822,0.009691397,0.002865277,0.0001434615,0.003632775],"genre_scores_gemma":[0.1082151,0.1607354,0.03835109,0.1444098,0.07290018,0.005061018,0.04788282,0.002333732,0.420111],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4164782,"threshold_uncertainty_score":0.9997872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04246406934857222,"score_gpt":0.3646480608111223,"score_spread":0.3221839914625501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}