{"id":"W1492560350","doi":"10.1002/ajh.23725","title":"A double‐blind, placebo‐controlled phase II study of the efficacy and safety of 2,2‐dimethylbutyrate (HQK‐1001), an oral fetal globin inducer, in sickle cell disease","year":2014,"lang":"en","type":"article","venue":"American Journal of Hematology","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"University of North Carolina at Chapel Hill; University of Illinois at Urbana-Champaign; Cairo University; Ain Shams University; Children's National Hospital; University of South Alabama; Virginia Commonwealth University; American University of Beirut","keywords":"Medicine; Fetal hemoglobin; Placebo; Internal medicine; Nausea; Gastroenterology; Adverse effect; Vomiting; Surgery; Anesthesia; Fetus; Pregnancy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009093068,0.000227607,0.001617506,0.0002784446,0.00008527298,0.000005548476,0.0002305193,0.00008684422,0.00002880669],"category_scores_gemma":[0.0002586495,0.0001387673,0.0001807463,0.0004752971,0.0006059548,0.00008011694,0.00009889491,0.0005306856,9.240833e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002901823,"about_ca_system_score_gemma":0.0002725886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002110849,"about_ca_topic_score_gemma":0.00004773928,"domain_scores_codex":[0.9972748,0.0006828084,0.001203388,0.0002243905,0.0003121574,0.0003025133],"domain_scores_gemma":[0.997637,0.0002732546,0.001243168,0.0003581733,0.0001757949,0.0003125897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7476258,0.04390209,0.1240176,0.000338258,0.001690592,0.0006233824,0.01523692,0.001120134,0.01474141,0.0005777776,0.0001959816,0.04993007],"study_design_scores_gemma":[0.8855027,0.06018174,0.02007551,0.0005168245,0.00243642,0.001097626,0.02345185,0.001966259,0.00364791,0.0001827978,0.0004176541,0.0005226905],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970722,0.000683186,0.00004089223,0.0009474879,0.0001360333,0.0008991541,0.000003909432,0.000006430604,0.0002107358],"genre_scores_gemma":[0.9995309,0.00009132155,0.0001377119,0.0001491146,0.00002878353,0.000007027784,0.000001662842,0.00002186193,0.00003163669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1378769,"threshold_uncertainty_score":0.5658765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220411106416139,"score_gpt":0.2967107348693855,"score_spread":0.2845066238052242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}