{"id":"W149315227","doi":"10.1007/978-1-61779-370-7_15","title":"Biodistribution and Shedding of AAV Vectors","year":2011,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Biodistribution; Vector (molecular biology); Computational biology; Capsid; Preclinical research; Medicine; Pharmacology; Biology; Bioinformatics; In vivo; Virology; Recombinant DNA; Biotechnology; Genetics; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001612039,0.0005365435,0.0004237961,0.0009612165,0.0003394984,0.001360053,0.0005822168,0.0006140937,0.002541177],"category_scores_gemma":[0.001445418,0.0005463889,0.0005296791,0.0004162881,0.0004780284,0.0007142546,0.0004289606,0.001211421,0.002991466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006609673,"about_ca_system_score_gemma":0.0006601529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008116165,"about_ca_topic_score_gemma":0.0008264399,"domain_scores_codex":[0.9989334,0.000195688,0.0001031718,0.0002081801,0.0004885604,0.00007100236],"domain_scores_gemma":[0.9994799,0.0001842736,0.0000761799,0.00005708577,0.0001649175,0.00003764607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001450298,0.0000529246,0.0005878257,0.001227222,0.00001846173,0.0001112993,0.0002759299,0.0008985212,0.8900712,0.003219831,0.004295625,0.09909611],"study_design_scores_gemma":[0.00001760263,0.0006267661,0.00291377,0.0004097427,0.00004073898,0.0009966756,0.0001270494,0.002131459,0.8661338,0.001532777,0.1249893,0.00008033193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2263136,0.1031485,0.5596379,0.002437775,0.0009590861,0.004061888,0.009298764,0.005950721,0.08819181],"genre_scores_gemma":[0.4028985,0.1150831,0.386349,0.001245639,0.000252927,0.004041418,0.01246784,0.001662866,0.07599884],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002541177,"threshold_uncertainty_score":0.008525372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04220180393356657,"score_gpt":0.40863400340775,"score_spread":0.3664321994741835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}