{"id":"W1493241342","doi":"10.1038/72221","title":"The envelope, please: Nuclear lamins and disease","year":2000,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Lamin; LMNA; Nuclear lamina; Pathogenesis; Disease; Myopathy; Medicine; Mutation; Genetics; Bioinformatics; Gene; Biology; Nuclear protein; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000766786,0.00008404032,0.00006232336,0.0000107802,0.000156818,0.000009975236,0.00008347418,0.000124844,0.0002853367],"category_scores_gemma":[0.0001338443,0.00004813854,0.0000190292,0.00005038039,0.0001436797,0.000001687612,0.0000211817,0.000181371,0.00001405811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003362176,"about_ca_system_score_gemma":0.0000157627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004762589,"about_ca_topic_score_gemma":0.000009495378,"domain_scores_codex":[0.9995156,0.00002051626,0.00007327244,0.0001707682,0.0001050789,0.0001147924],"domain_scores_gemma":[0.9996126,0.000009698309,0.00001749886,0.0002114828,0.00002485879,0.0001238584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00138557,0.00003225108,0.001913188,0.00003305803,0.0001066548,0.00003309085,0.0001825972,0.000003182329,0.07845861,0.005484433,0.5115812,0.4007861],"study_design_scores_gemma":[0.0003592303,0.0001123394,0.02589145,0.000009156553,0.00002107926,0.00001407538,0.00003078083,0.00001407342,0.0002244293,0.0002580626,0.9730013,0.00006402944],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956625,0.01471699,0.00001006254,0.01147107,0.0004356067,0.0001457477,0.000009071301,0.00002410563,0.01656229],"genre_scores_gemma":[0.9869461,0.002011136,0.00004745935,0.004345897,0.0009283993,0.000001906293,0.00004738705,0.00001565368,0.005656034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.46142,"threshold_uncertainty_score":0.3124237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001936987364538731,"score_gpt":0.2110207702840774,"score_spread":0.2090837829195386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}