{"id":"W1493241342","doi":"10.1038/72221","title":"The envelope, please: Nuclear lamins and disease","year":2000,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Lamin; LMNA; Nuclear lamina; Pathogenesis; Disease; Myopathy; Medicine; Mutation; Genetics; Bioinformatics; Gene; Biology; Nuclear protein; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000665136,0.0005170117,0.000660409,0.0007293918,0.000580553,0.00239249,0.0005026399,0.003230809,0.01679199],"category_scores_gemma":[0.001262757,0.0001852316,0.0002218409,0.0006004861,0.001207786,0.003156995,0.0008534444,0.00224998,0.01089585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000519495,"about_ca_system_score_gemma":0.0004415694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003618025,"about_ca_topic_score_gemma":0.0006442217,"domain_scores_codex":[0.9997365,0.00007760609,0.00002704497,0.00005352101,0.00007606934,0.00002929335],"domain_scores_gemma":[0.9995373,0.0001717193,0.00007991478,0.0000360509,0.00006544942,0.000109514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007381423,0.00007655388,0.001372056,0.00157242,0.00006497309,0.00124026,0.0002638942,0.0002237389,0.02675142,0.03885814,0.4830851,0.4457533],"study_design_scores_gemma":[0.00003228518,0.00008309358,0.00105961,0.0002893711,0.00002935548,0.002885185,0.000150655,0.0001401757,0.004287936,0.01279146,0.9782296,0.00002127884],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009589576,0.6626934,0.006069313,0.1452055,0.1054404,0.00005955075,0.000437845,0.0007513887,0.06975306],"genre_scores_gemma":[0.08121081,0.4424952,0.006229158,0.05913331,0.08698814,0.00008330201,0.0005390504,0.0003151265,0.3230059],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01679199,"threshold_uncertainty_score":0.05617481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001936987364538731,"score_gpt":0.2110207702840774,"score_spread":0.2090837829195386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}