{"id":"W1493379410","doi":"10.1074/jbc.m103720200","title":"Mechanistic Basis for Kinetic Differences between the Rat α1, α2, and α3 Isoforms of the Na,K-ATPase","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Medical Research Council; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Vanadate; Gene isoform; Affinities; Protein subunit; Stereochemistry; ATPase; Kinetics; Enzyme; Biophysics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002036004,0.000106507,0.0001787478,0.000007231825,0.00008146135,0.000008918001,0.0002106666,0.0001680059,0.00002656243],"category_scores_gemma":[0.0001301158,0.00004673762,0.0001636095,0.00005248489,0.0001576229,0.000002541802,0.0000345624,0.00009802162,1.137526e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006130631,"about_ca_system_score_gemma":0.0000258035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001175159,"about_ca_topic_score_gemma":6.125842e-7,"domain_scores_codex":[0.9993353,0.00002071952,0.0002988442,0.0001124778,0.0001049847,0.0001276618],"domain_scores_gemma":[0.9994075,0.00005641995,0.0002591376,0.0001212229,0.0001051731,0.00005056634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001690006,0.00003701645,0.02855628,0.00003733431,0.00004914036,0.000001481784,0.00001790303,0.000005765252,0.969297,0.00002377453,0.00008422705,0.001721109],"study_design_scores_gemma":[0.0005031467,0.0003668219,0.07027124,0.0000416058,0.00007715532,0.00007646625,0.0001400589,0.00002407542,0.9251485,0.001102657,0.002137462,0.0001108145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966025,0.0004668309,0.002317514,0.0003761303,0.00007151382,0.00008354327,0.00001808439,0.000001724338,0.00006218568],"genre_scores_gemma":[0.9990263,0.0002944867,0.0001005223,0.00005513039,0.0003527199,0.000004031854,0.00001490766,0.000004775465,0.0001470975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04414847,"threshold_uncertainty_score":0.1905905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02228624424127115,"score_gpt":0.2373842288654723,"score_spread":0.2150979846242011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}