{"id":"W1493421534","doi":"10.1002/stem.1956","title":"Concise Review: Bullseye: Targeting Cancer Stem Cells to Improve the Treatment of Gliomas by Repurposing Disulfiram","year":2015,"lang":"en","type":"review","venue":"Stem Cells","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Cuccione Foundation; BC Children's Hospital; Children's Hospital Foundation; Hannah's Heroes Foundation","keywords":"Temozolomide; Cancer stem cell; Cancer research; Biology; Cancer; Drug repositioning; Synthetic lethality; Cancer cell; Disulfiram; Chemotherapy; Glioma; Bioinformatics; Oncology; DNA repair; Pharmacology; Medicine; Drug; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007884311,0.001621354,0.001939596,0.001644547,0.0004482282,0.002041177,0.001883818,0.003296709,0.008389509],"category_scores_gemma":[0.001447773,0.000331003,0.0009362618,0.001557181,0.0005901961,0.00212231,0.001269306,0.004200418,0.004953017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001048484,"about_ca_system_score_gemma":0.001417793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006353635,"about_ca_topic_score_gemma":0.001045151,"domain_scores_codex":[0.9995983,0.00005603549,0.00005092814,0.0000776911,0.0001587767,0.00005834954],"domain_scores_gemma":[0.99934,0.0001146461,0.00009561866,0.00001588119,0.0002656768,0.0001681777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002241674,0.0001090222,0.000099518,0.01239697,0.0001283423,0.0002856027,0.00005312701,0.0002808547,0.001937937,0.001712273,0.7034429,0.2793292],"study_design_scores_gemma":[0.00005748836,0.0001562006,0.000376916,0.001312697,0.0001028169,0.0005140446,0.00003625707,0.00008305059,0.0005940304,0.0007589661,0.9959821,0.00002557156],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000566068,0.919974,0.0007089846,0.01242964,0.06124188,0.0001209089,0.0003386687,0.0001163322,0.004503642],"genre_scores_gemma":[0.001798116,0.9364591,0.000450418,0.01372364,0.03632413,0.0001118714,0.0005736646,0.00002522532,0.01053376],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008389509,"threshold_uncertainty_score":0.02806568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04176035684256271,"score_gpt":0.3411673909769427,"score_spread":0.29940703413438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}