{"id":"W1493450043","doi":"10.1371/journal.pgen.1000976","title":"Use of Genome-Wide Expression Data to Mine the “Gray Zone” of GWA Studies Leads to Novel Candidate Obesity Genes","year":2010,"lang":"en","type":"book-chapter","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Provincia autonoma di Bolzano - Alto Adige; Tartu Ülikool; Sydäntutkimussäätiö; Universitair Medisch Centrum Groningen; Medical Research Council; Leids Universitair Medisch Centrum; Novo Nordisk; Bundesministerium für Bildung und Forschung; Academy of Finland; Rivierduinen; GGZ Friesland; King's College London; Lunds Universitet; Karolinska Institutet; ZonMw; Latvijas Universitate; GGZ Drenthe; Helsingin Yliopisto; European Commission; Lentis; Münchner Zentrum für Gesundheitswissenschaften; Vrije Universiteit Amsterdam; University of Oxford; Royal Society; University of Leicester; Norwegian Institute of Public Health; Biomedicum Helsinki-säätiö; Queen's University; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; National Heart, Lung, and Blood Institute; Erasmus Universitair Medisch Centrum Rotterdam; Helsingin ja Uudenmaan Sairaanhoitopiiri; Imperial College London; Universiteit Leiden; Jalmari ja Rauha Ahokkaan Säätiö; Centre for Medical Systems Biology; Foundation for Cardiovascular Research; Pfizer; European Molecular Biology Laboratory; Abbott Laboratories","keywords":"Gene; Candidate gene; Computational biology; Biology; Genetics; Genome; Genome-wide association study; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00201928,0.0003837528,0.0008562139,0.001637014,0.0004283111,0.001012058,0.0004244939,0.0003708864,0.000718949],"category_scores_gemma":[0.004690808,0.000277381,0.0005955668,0.001587991,0.0006105295,0.000365332,0.0006895975,0.0007492708,0.0003236419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002600602,"about_ca_system_score_gemma":0.000316202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009412335,"about_ca_topic_score_gemma":0.001726513,"domain_scores_codex":[0.9992127,0.0002584193,0.00005414552,0.0002888407,0.0001409282,0.00004482003],"domain_scores_gemma":[0.99624,0.002584134,0.0005414097,0.0004046428,0.0001415923,0.00008820448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008258974,0.0002034204,0.5724114,0.0002717474,0.001093104,0.0008701819,0.0008368714,0.007378786,0.3204709,0.003248883,0.0009920258,0.09139694],"study_design_scores_gemma":[0.0001544033,0.0004694971,0.8546026,0.00008443842,0.0008912089,0.001807447,0.001016463,0.05471834,0.05920213,0.01830744,0.008657782,0.00008835393],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8873162,0.001136011,0.108047,0.0005295529,0.00002294185,0.00007152858,0.001348244,0.0003049199,0.00122358],"genre_scores_gemma":[0.9238062,0.0006769394,0.07237061,0.0003300121,0.00003824141,0.000126692,0.002130116,0.00007742162,0.0004437568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00201928,"threshold_uncertainty_score":0.01067913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1028108463898279,"score_gpt":0.3030587376884051,"score_spread":0.2002478912985772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}