{"id":"W1493459286","doi":"10.1038/cti.2015.8","title":"A GMCSF and IL7 fusion cytokine leads to functional thymic‐dependent T‐cell regeneration in age‐associated immune deficiency","year":2015,"lang":"en","type":"article","venue":"Clinical & Translational Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute for Research in Immunology and Cancer","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Georgia Cancer Coalition","keywords":"Biology; Lymphopoiesis; CD8; Immunology; T cell; Thymic involution; Immune system; IL-2 receptor; Cytokine; Progenitor cell; Cell biology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001507838,0.0003877142,0.0007785664,0.0003709423,0.0002575342,0.00003083924,0.0003527763,0.001101159,0.0004337226],"category_scores_gemma":[0.000436154,0.0003689683,0.0001921518,0.0004233132,0.0006855057,0.0001977696,0.0001769816,0.001182,0.0009105291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001107285,"about_ca_system_score_gemma":0.0003386185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002331618,"about_ca_topic_score_gemma":0.0004837626,"domain_scores_codex":[0.995795,0.001014365,0.001507385,0.0008553062,0.0001359341,0.0006919705],"domain_scores_gemma":[0.9982436,0.000726245,0.0002793371,0.0004006426,0.0002652075,0.00008497034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001451104,0.001225526,0.01845274,0.000007434599,0.0001113094,0.00002677349,0.0004639917,0.0002910106,0.9710639,0.001873544,0.0006950893,0.004337588],"study_design_scores_gemma":[0.04517363,0.006843464,0.6801111,0.0001804236,0.0003725336,0.0005600967,0.0009991804,0.0002273666,0.200315,0.01154766,0.05135189,0.002317638],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798093,0.01111687,0.000908912,0.003604267,0.002493383,0.0005189688,0.00005723845,0.0001146693,0.001376401],"genre_scores_gemma":[0.9935975,0.0004656617,0.0002631854,0.0005410602,0.00009014974,0.00005360234,0.001037248,0.00003447719,0.003917121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7707489,"threshold_uncertainty_score":0.9998762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04968244531826236,"score_gpt":0.2939424062470161,"score_spread":0.2442599609287538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}