{"id":"W1493565145","doi":"10.1186/s12896-015-0152-x","title":"Critical assessment of influenza VLP production in Sf9 and HEK293 expression systems","year":2015,"lang":"en","type":"article","venue":"BMC Biotechnology","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Waterloo; Polytechnique Montréal; National Research Council Canada","funders":"Natural Sciences and Engineering Research Council of Canada; University of Waterloo","keywords":"Sf9; Virology; HEK 293 cells; Biology; Virus; Virus-like particle; Viral matrix protein; Hemagglutinin (influenza); Influenza vaccine; Cell culture; Genetics; Gene; Recombinant DNA; Spodoptera","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002483058,0.0008991687,0.000601346,0.0004529123,0.0003901697,0.0009390398,0.0007664732,0.0006727591,0.0007332087],"category_scores_gemma":[0.002427682,0.0002878376,0.0005967251,0.0006518427,0.0002992658,0.0006180771,0.0005033877,0.0008286388,0.0006134359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00114478,"about_ca_system_score_gemma":0.0004286214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001967336,"about_ca_topic_score_gemma":0.00182248,"domain_scores_codex":[0.9978041,0.0005795544,0.0003144357,0.0002111737,0.0009516527,0.0001390892],"domain_scores_gemma":[0.9987592,0.0005022095,0.0001755419,0.00008370705,0.0004385797,0.00004084647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003017672,0.0001467086,0.0008112319,0.0003885924,0.00003157269,0.0001925607,0.0001775077,0.0008299796,0.9911476,0.0001808114,0.0001717875,0.00562],"study_design_scores_gemma":[0.00001180668,0.0006513369,0.002498048,0.00003184485,0.00005828023,0.0002417504,0.00007899812,0.002783475,0.9898254,0.00006408864,0.003735225,0.00001978661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8927757,0.008246162,0.08477061,0.0007262385,0.0002310442,0.001301809,0.003965805,0.000594085,0.00738852],"genre_scores_gemma":[0.8585516,0.008538279,0.1191837,0.0002343319,0.00005977085,0.001194119,0.008551468,0.0001871979,0.003499599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002483058,"threshold_uncertainty_score":0.0131318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02945411602883017,"score_gpt":0.3371386211742962,"score_spread":0.307684505145466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}