{"id":"W1493954171","doi":"10.1074/jbc.m011437200","title":"Tyrosine-phosphorylated Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Associates with the Adaptor Protein SHC in SRC-transformed Cells","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"LRP1; Proto-oncogene tyrosine-protein kinase Src; Phosphotyrosine-binding domain; Signal transducing adaptor protein; Phosphorylation; Tyrosine phosphorylation; Cell biology; SH3 domain; Tyrosine; LDL receptor; Protein tyrosine phosphatase; SH2 domain; Biology; Chemistry; Biochemistry; Lipoprotein; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582932,0.0003391471,0.0002212288,0.0002686039,0.0002952387,0.0004640179,0.0002725828,0.0003959092,0.001183764],"category_scores_gemma":[0.0001956577,0.0003291405,0.0003295631,0.0002548861,0.0002214303,0.0002359335,0.0003875899,0.0006021082,0.001047734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004830129,"about_ca_system_score_gemma":0.0002122445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092235,"about_ca_topic_score_gemma":0.0008477863,"domain_scores_codex":[0.9997863,0.00002522187,0.00001458196,0.00004737713,0.00007629953,0.00005033131],"domain_scores_gemma":[0.9998764,0.00001442762,0.00004172861,0.00001876363,0.00001332425,0.00003538753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003756209,0.00001205303,0.0004158388,0.00001938972,0.000003817393,0.0001019554,0.000008765433,0.00002765165,0.9988256,0.00006457757,0.00003773165,0.0004451194],"study_design_scores_gemma":[0.00001760781,0.000113909,0.02208711,0.000007227059,0.00001538648,0.001582316,0.00004455182,0.001899446,0.9702418,0.0001149587,0.003869595,0.000006092588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943911,0.001999288,0.00196602,0.0001947612,0.00002794806,0.00001077498,0.0001920819,0.00007093036,0.001147005],"genre_scores_gemma":[0.9933252,0.001083881,0.00107601,0.00005571783,0.00001499007,0.00001835561,0.0009512305,0.00001588685,0.003458649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001183764,"threshold_uncertainty_score":0.003960133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009575558564097468,"score_gpt":0.2072376223742108,"score_spread":0.1976620638101133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}