{"id":"W1494012992","doi":"10.1139/y07-111","title":"Synergistic cytotoxic effects of tamoxifen and black cohosh on MCF-7 and MDA-MB-231 human breast cancer cells: an in vitro studyThis article is one of a selection of papers published in this special issue (part 2 of 2) on the Safety and Efficacy of Natural Health Products.","year":2007,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-François d'Assise","funders":"","keywords":"Black cohosh; MCF-7; Tamoxifen; Cell growth; Growth inhibition; Cytotoxicity; Antiestrogen; Pharmacology; Cytotoxic T cell; Endocrinology; Chemistry; Estrogen; Internal medicine; In vitro; Cancer cell; Breast cancer; Biology; Medicine; Cancer; Biochemistry; Human breast","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018489,0.0005757764,0.000509297,0.0003117574,0.0002716929,0.0002260172,0.000217644,0.0003125524,0.001783362],"category_scores_gemma":[0.0001531788,0.0001849441,0.0004922572,0.0002741646,0.000157862,0.0001954478,0.0003468529,0.0003048986,0.0003385022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002139924,"about_ca_system_score_gemma":0.0002646551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000921086,"about_ca_topic_score_gemma":0.003153748,"domain_scores_codex":[0.999772,0.00005374695,0.00001651438,0.00003206421,0.00007716617,0.00004851888],"domain_scores_gemma":[0.9998696,0.00003720949,0.00002483837,0.00001102441,0.00003662611,0.00002077259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005241464,0.0001331769,0.0006201809,0.0002335493,0.00004425823,0.0001544083,0.0000661113,0.0000850051,0.9937081,0.00004848875,0.0001329,0.004249603],"study_design_scores_gemma":[0.00003178225,0.002851226,0.007280407,0.00001618641,0.0001380489,0.0005347471,0.0001260851,0.0003362643,0.985018,0.00003509838,0.003620552,0.00001167446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793051,0.01569989,0.001107229,0.0002292321,0.0001294358,0.00007371569,0.0004332832,0.00003195698,0.002990096],"genre_scores_gemma":[0.9774505,0.01264198,0.002729501,0.0001842194,0.00009229159,0.0001044384,0.0007614726,0.00001677203,0.006018865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001783362,"threshold_uncertainty_score":0.005965948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005588341938926114,"score_gpt":0.2572238983126164,"score_spread":0.2516355563736903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}