{"id":"W1494949608","doi":"10.1074/jbc.m105160200","title":"Mutation of Trp1254 in the Multispecific Organic Anion Transporter, Multidrug Resistance Protein 2 (MRP2) (ABCC2), Alters Substrate Specificity and Results in Loss of Methotrexate Transport Activity","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Multidrug resistance-associated protein 2; Organic anion transporter 1; Transporter; Methotrexate; Chemistry; Substrate (aquarium); Multiple drug resistance; Transport protein; Mutation; Multidrug Resistance-Associated Proteins; Organic anion; Biochemistry; Pharmacology; ATP-binding cassette transporter; Biology; Ion; Medicine; Internal medicine; Gene; Organic chemistry; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317481,0.0005381531,0.0002691502,0.0001783864,0.0001642819,0.0002602978,0.0002775757,0.0003901988,0.001411986],"category_scores_gemma":[0.0002711686,0.0001425756,0.0004832646,0.0001671211,0.0003532772,0.0001380215,0.0002282765,0.0004820764,0.0004274872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002715095,"about_ca_system_score_gemma":0.0002301514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001035054,"about_ca_topic_score_gemma":0.0006698339,"domain_scores_codex":[0.9997885,0.00005571611,0.00003159895,0.00004400153,0.00004825972,0.00003193639],"domain_scores_gemma":[0.9997974,0.00005594486,0.00007601023,0.00002187734,0.00001209308,0.00003669801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001561356,0.00005104797,0.0002056278,0.00002031373,0.00001226812,0.000230639,0.00001211381,0.00009849403,0.9984477,0.00005550131,0.0000211816,0.0006890477],"study_design_scores_gemma":[0.00005415287,0.0007230868,0.003961414,0.000005786324,0.00004714419,0.0009542525,0.00003541066,0.001095713,0.9913492,0.00003754413,0.001721609,0.00001467081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979385,0.0002321467,0.001116633,0.00003902712,0.00002566395,0.00002857977,0.0001475711,0.00003459544,0.0004371821],"genre_scores_gemma":[0.9968593,0.0002177168,0.001477311,0.00003956113,0.000009915367,0.00002142042,0.0002878272,0.00002912713,0.001057907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411986,"threshold_uncertainty_score":0.004723549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02904974113978437,"score_gpt":0.2658050240517115,"score_spread":0.2367552829119272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}