{"id":"W1494949608","doi":"10.1074/jbc.m105160200","title":"Mutation of Trp1254 in the Multispecific Organic Anion Transporter, Multidrug Resistance Protein 2 (MRP2) (ABCC2), Alters Substrate Specificity and Results in Loss of Methotrexate Transport Activity","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Multidrug resistance-associated protein 2; Organic anion transporter 1; Transporter; Methotrexate; Chemistry; Substrate (aquarium); Multiple drug resistance; Transport protein; Mutation; Multidrug Resistance-Associated Proteins; Organic anion; Biochemistry; Pharmacology; ATP-binding cassette transporter; Biology; Ion; Medicine; Internal medicine; Gene; Organic chemistry; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001573991,0.0002124994,0.0007100942,0.00008312782,0.00002551894,0.000004537639,0.0001870211,0.000233741,0.00003831068],"category_scores_gemma":[0.0000723434,0.000131211,0.0001767365,0.0004188815,0.0002484006,0.00009402906,0.000003856716,0.0005653082,1.496196e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006028253,"about_ca_system_score_gemma":0.00007134049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002558081,"about_ca_topic_score_gemma":0.0001599989,"domain_scores_codex":[0.9977311,0.0001133795,0.001273526,0.00027794,0.0003652255,0.000238824],"domain_scores_gemma":[0.9986851,0.0001191674,0.0007773536,0.0002003231,0.0001255794,0.00009254014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008798584,0.0007392028,0.03133295,0.0003318344,0.0000292214,0.001327268,0.0008535649,0.00001661451,0.9557806,0.000007782399,0.000001746204,0.0007805821],"study_design_scores_gemma":[0.003327896,0.0001775808,0.448883,0.0004775106,0.00003260194,0.0001069111,0.0006656519,0.00001555895,0.5460187,0.0001315846,0.0000604598,0.0001025202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979482,0.0003826212,0.0004860834,0.0004758747,0.00003055783,0.0003404705,0.00004264784,0.000006585605,0.0002869325],"genre_scores_gemma":[0.9977009,0.0009648334,0.001151992,0.00001103836,0.00005532475,0.000004404227,0.00002274918,0.00001056838,0.00007816299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4175501,"threshold_uncertainty_score":0.5350629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02904974113978437,"score_gpt":0.2658050240517115,"score_spread":0.2367552829119272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}