{"id":"W1495232163","doi":"10.1002/jbmr.2158","title":"Increased IL-6 Expression in Osteoclasts Is Necessary But Not Sufficient for the Development of Paget's Disease of Bone","year":2013,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone health and treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; National Institutes of Health; U.S. Department of Defense","keywords":"Transgene; RANKL; Genetically modified mouse; Mutant; Phenotype; Biology; Molecular biology; Endocrinology; Immunology; Cell biology; Receptor; Activator (genetics); Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001619922,0.0003066138,0.0003535362,0.0003712757,0.0001980299,0.0003422489,0.0002810254,0.0004485518,0.00179036],"category_scores_gemma":[0.0001763995,0.0002612334,0.0003164312,0.0002394788,0.0003508245,0.0002102749,0.0002657373,0.0009299705,0.0004750641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002886186,"about_ca_system_score_gemma":0.0002071551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000479265,"about_ca_topic_score_gemma":0.001127416,"domain_scores_codex":[0.9996302,0.00002733889,0.00005711559,0.00008581691,0.0001223908,0.00007709182],"domain_scores_gemma":[0.9996908,0.00003894186,0.0001253325,0.00003055203,0.00001893611,0.00009548106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001212491,0.00006015949,0.0004611762,0.00002932295,0.000003763179,0.0001969744,0.00002234645,0.00002460094,0.99847,0.00008288689,0.0000258086,0.0005015762],"study_design_scores_gemma":[0.0002061162,0.001600898,0.02630724,0.00002819498,0.00007606643,0.004350376,0.0001581642,0.001606134,0.9584389,0.0001818696,0.007026507,0.00001955065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968144,0.0006934227,0.001279924,0.00009171198,0.00002773475,0.00003294391,0.0004387962,0.00005905912,0.0005620834],"genre_scores_gemma":[0.9935726,0.0007246477,0.001885065,0.00006700931,0.00002163065,0.00006433961,0.000964102,0.00003235109,0.00266825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179036,"threshold_uncertainty_score":0.005989373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07181706112366319,"score_gpt":0.3765926736851544,"score_spread":0.3047756125614912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}