{"id":"W1495483872","doi":"10.1111/j.1471-4159.2011.07515.x","title":"Regulation of β‐site APP‐cleaving enzyme 1 gene expression and its role in Alzheimer’s Disease","year":2011,"lang":"en","type":"review","venue":"Journal of Neurochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Senile plaques; BACE1-AS; Amyloid precursor protein; Pathogenesis; Alzheimer's disease; Amyloid precursor protein secretase; Translation (biology); Neuropathology; Biology; Gene expression; Neuroscience; Alpha secretase; Regulation of gene expression; Disease; Gene; Medicine; Messenger RNA; Genetics; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002648805,0.0006541798,0.001108691,0.001211492,0.0002068404,0.0005679157,0.0006089236,0.0006933847,0.002217528],"category_scores_gemma":[0.0002399258,0.0002055847,0.0002683295,0.001461841,0.0002658927,0.0006790439,0.0003774312,0.0007754221,0.002615962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004235331,"about_ca_system_score_gemma":0.0006107215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007086523,"about_ca_topic_score_gemma":0.001101897,"domain_scores_codex":[0.9999071,0.00001355624,0.00001299258,0.00001726842,0.0000388754,0.00001022557],"domain_scores_gemma":[0.9999216,0.00002225802,0.00001577688,0.000002630919,0.00002725454,0.00001047835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001116901,0.00009447373,0.000223059,0.01664063,0.00006561646,0.0004576534,0.00006585599,0.0003337677,0.01128941,0.002829212,0.0181356,0.949753],"study_design_scores_gemma":[0.00003360904,0.0001609092,0.002385305,0.001992421,0.0001018111,0.002441709,0.00006430908,0.00008422458,0.002576119,0.001840175,0.9882961,0.0000233699],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002669466,0.9984302,0.0001101082,0.000100689,0.00008883939,0.000004186249,0.00001611226,0.000006152119,0.000976754],"genre_scores_gemma":[0.0009768058,0.9980063,0.0001582044,0.0000695986,0.00005811771,0.000006160625,0.00002651812,9.222506e-7,0.0006974023],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002217528,"threshold_uncertainty_score":0.007418394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06089647946382759,"score_gpt":0.3417003211484792,"score_spread":0.2808038416846516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}