{"id":"W1495971429","doi":"10.1002/pat.3619","title":"Engineering recombinant antibodies for polymer biofunctionalization","year":2015,"lang":"en","type":"article","venue":"Polymers for Advanced Technologies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Irish Research Council; Science Foundation Ireland; Enterprise Ireland; FP7 People: Marie-Curie Actions; European Commission","keywords":"Glycan; Linker; Combinatorial chemistry; Protein engineering; Surface modification; Recombinant DNA; Escherichia coli; Chemistry; Antibody; Cysteine; Bioconjugation; Amine gas treating; Covalent bond; Polymer; Maleimide; Biochemistry; Biophysics; Polymer chemistry; Biology; Enzyme; Glycoprotein; Organic chemistry; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000129068,0.0001931841,0.0003016498,0.0002852448,0.0001164117,0.00001683338,0.0001330573,0.0001417877,0.00001169734],"category_scores_gemma":[0.0006985542,0.0001562965,0.0001516607,0.0002603855,0.0001358519,0.0001327803,0.00006773722,0.0001152616,0.000009795995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007864863,"about_ca_system_score_gemma":0.00008706452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001232498,"about_ca_topic_score_gemma":0.000002120665,"domain_scores_codex":[0.9987984,0.000004434573,0.0002313927,0.0003097772,0.000212656,0.0004432825],"domain_scores_gemma":[0.9992536,0.0001504871,0.00006608453,0.0002221284,0.0002183689,0.00008937724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005006698,0.0004104501,0.008857205,0.001084949,0.0005086084,0.00001663781,0.0002097292,0.0002232561,0.2197227,0.0926332,0.01258349,0.6587431],"study_design_scores_gemma":[0.003650764,0.001431929,0.0003469875,0.0001486882,0.00008201387,0.0000638325,0.0009904036,0.003060059,0.6938887,0.008204854,0.287717,0.0004146981],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5299784,0.1120838,0.251871,0.07483568,0.006440201,0.01007514,0.0007273599,0.008454134,0.005534287],"genre_scores_gemma":[0.8945861,0.001427705,0.07159483,0.0003330643,0.0002806779,0.00158261,0.0006244421,0.000142854,0.02942765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6583284,"threshold_uncertainty_score":0.6373585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04611800544331999,"score_gpt":0.324396531621878,"score_spread":0.278278526178558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}