{"id":"W1495971429","doi":"10.1002/pat.3619","title":"Engineering recombinant antibodies for polymer biofunctionalization","year":2015,"lang":"en","type":"article","venue":"Polymers for Advanced Technologies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Irish Research Council; Science Foundation Ireland; Enterprise Ireland; FP7 People: Marie-Curie Actions; European Commission","keywords":"Glycan; Linker; Combinatorial chemistry; Protein engineering; Surface modification; Recombinant DNA; Escherichia coli; Chemistry; Antibody; Cysteine; Bioconjugation; Amine gas treating; Covalent bond; Polymer; Maleimide; Biochemistry; Biophysics; Polymer chemistry; Biology; Enzyme; Glycoprotein; Organic chemistry; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004126555,0.0005695017,0.0002185375,0.0003887819,0.0001186275,0.0003741395,0.0003336259,0.0003842672,0.0013916],"category_scores_gemma":[0.000317533,0.0002182408,0.0003186797,0.0004251155,0.0001768468,0.0003221041,0.000317425,0.0006748632,0.001175961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004354705,"about_ca_system_score_gemma":0.0001609087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001886123,"about_ca_topic_score_gemma":0.0002452719,"domain_scores_codex":[0.999759,0.00004087029,0.00002359882,0.00005198154,0.00007611105,0.00004838507],"domain_scores_gemma":[0.9998859,0.00002693457,0.00003514176,0.0000162736,0.00002341741,0.00001230274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001186928,0.00001752969,0.00005089513,0.0000941445,0.000006904684,0.0000487838,0.00001575562,0.0001572022,0.9906766,0.0006586803,0.0000980455,0.008163512],"study_design_scores_gemma":[0.000006806373,0.00005423966,0.0002658172,0.00001011586,0.00001078993,0.0001492922,0.000005245236,0.0006193703,0.9855558,0.0001291684,0.01318914,0.000004306294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5923235,0.01231301,0.3755745,0.0005652272,0.000342827,0.0005102766,0.0008905783,0.001042456,0.01643774],"genre_scores_gemma":[0.8257867,0.008693233,0.1495485,0.0003365636,0.00005229322,0.0003489763,0.001424706,0.0002403337,0.01356866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0013916,"threshold_uncertainty_score":0.004655302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04611800544331999,"score_gpt":0.324396531621878,"score_spread":0.278278526178558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}