{"id":"W1495983964","doi":"10.1159/000319808","title":"Genetic Studies in Treatment-Resistant Schizophrenia","year":2010,"lang":"en","type":"book-chapter","venue":"Advances in biological psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Clozapine; Schizophrenia (object-oriented programming); Antipsychotic; Pharmacogenetics; Psychiatry; Medicine; Genetic association; Bioinformatics; Psychology; Genetics; Gene; Genotype; Biology; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009936577,0.0002407431,0.0001830565,0.001077675,0.0001788618,0.0003267272,0.000290644,0.0006684128,0.005245583],"category_scores_gemma":[0.00122722,0.0001161544,0.0001552918,0.0008412729,0.0005066881,0.0003191412,0.0004059254,0.0003701663,0.0009820946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003514313,"about_ca_system_score_gemma":0.0002630833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002087523,"about_ca_topic_score_gemma":0.00417472,"domain_scores_codex":[0.9996948,0.0001584952,0.00001802142,0.00003393073,0.00008582966,0.000008968758],"domain_scores_gemma":[0.9993144,0.0005525168,0.00004074628,0.00002096695,0.00003571309,0.00003563817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0005593753,0.0002498305,0.03547297,0.001659152,0.0001468643,0.0112657,0.00395235,0.0008588208,0.01814355,0.07071858,0.1692885,0.6876844],"study_design_scores_gemma":[0.0001761783,0.0003898214,0.1518888,0.002246408,0.0001415003,0.02412511,0.001412807,0.000551425,0.003692264,0.05938689,0.7559046,0.00008408575],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.167775,0.4597449,0.007077657,0.04054176,0.002491671,0.0001452472,0.001172335,0.0002256625,0.3208258],"genre_scores_gemma":[0.3420199,0.464204,0.01693109,0.01884359,0.00406863,0.0001589456,0.00118367,0.0001669092,0.1524232],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005245583,"threshold_uncertainty_score":0.01754826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06024105754820785,"score_gpt":0.3673782134824425,"score_spread":0.3071371559342346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}