{"id":"W1495997476","doi":"10.1046/j.1471-4159.2002.01210.x","title":"Microglia enhance β‐amyloid peptide‐induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species","year":2002,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":295,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research","funders":"","keywords":"Neurotoxicity; Microglia; Neuron; Neurotoxin; NADPH oxidase; Superoxide dismutase; Chemistry; Biology; Reactive oxygen species; Neuroscience; Biochemistry; Toxicity; Oxidative stress; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410913,0.0005956996,0.0002710269,0.0002489561,0.0001753785,0.000267168,0.0001323113,0.0002506373,0.0008178669],"category_scores_gemma":[0.0001126422,0.0001317781,0.0002785606,0.0001204322,0.0001790264,0.0002220364,0.0002391506,0.0002877992,0.0003213048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001359995,"about_ca_system_score_gemma":0.0001974819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004958348,"about_ca_topic_score_gemma":0.0009400917,"domain_scores_codex":[0.9998806,0.00003141849,0.00001086646,0.00001431017,0.00003233209,0.00003052171],"domain_scores_gemma":[0.9999324,0.00001280531,0.00001861877,0.00000550905,0.00001805223,0.00001272705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001976126,0.0000552436,0.0006151539,0.0001218743,0.00001509939,0.0002921055,0.00006051315,0.00005659289,0.9962454,0.00006097707,0.0000290268,0.002250356],"study_design_scores_gemma":[0.00003123568,0.0009797402,0.02755202,0.00003780181,0.00009171052,0.0008695114,0.0002471956,0.0005344728,0.9668936,0.0003393495,0.002412401,0.00001096512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891164,0.007582324,0.001502216,0.00007428364,0.00003643672,0.0000388878,0.0001047109,0.00003173542,0.001513048],"genre_scores_gemma":[0.9861806,0.008150667,0.002770966,0.00008903367,0.00003078198,0.00007319939,0.0001564492,0.000007471686,0.002540865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008178669,"threshold_uncertainty_score":0.002736032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03238695753752611,"score_gpt":0.2569164553267979,"score_spread":0.2245294977892718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}