{"id":"W1496096031","doi":"10.1074/jbc.m101852200","title":"GGA·TCC-interrupted Triplets in Long GAA·TTC Repeats Inhibit the Formation of Triplex and Sticky DNA Structures, Alleviate Transcription Inhibition, and Reduce Genetic Instabilities","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences","keywords":"Frataxin; DNA; Intron; Gene; Genetics; Nuclease; Biology; Escherichia coli; Ataxia; Molecular biology; Direct repeat; Transcription (linguistics); Trinucleotide repeat expansion; Chemistry; Iron-binding proteins; Allele; Base sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008579636,0.000325686,0.0002877896,0.0001795432,0.00009062031,0.0001446082,0.0001703618,0.000305436,0.0008721843],"category_scores_gemma":[0.0001240582,0.0001020976,0.0002444788,0.0001092212,0.0001586453,0.00008042835,0.0001304255,0.0004579939,0.0002670303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001207601,"about_ca_system_score_gemma":0.0001718137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006224405,"about_ca_topic_score_gemma":0.0007923522,"domain_scores_codex":[0.9998711,0.00002065605,0.00001323951,0.00002559602,0.00003792672,0.00003144578],"domain_scores_gemma":[0.9998523,0.00002110095,0.00005031481,0.00001620743,0.00001307809,0.00004700553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001014863,0.0000563247,0.00006259479,0.00001846787,0.000006630912,0.00002237037,0.000006519772,0.00007129848,0.9985399,0.00003084288,0.00002329907,0.001060226],"study_design_scores_gemma":[0.00003469047,0.001688365,0.003140929,0.000009491284,0.00003194888,0.0002087867,0.00001211647,0.001033979,0.9917954,0.00004463427,0.001992818,0.000006898533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969484,0.0009309907,0.001189606,0.00003219322,0.00002141576,0.0000216669,0.00007747104,0.00008936228,0.0006887696],"genre_scores_gemma":[0.9963315,0.0004132424,0.001572959,0.00004219795,0.00001108882,0.00003034347,0.0002209636,0.00002923591,0.001348569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008721843,"threshold_uncertainty_score":0.002917767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04712634227196113,"score_gpt":0.2678164514971052,"score_spread":0.2206901092251441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}