{"id":"W1496096031","doi":"10.1074/jbc.m101852200","title":"GGA·TCC-interrupted Triplets in Long GAA·TTC Repeats Inhibit the Formation of Triplex and Sticky DNA Structures, Alleviate Transcription Inhibition, and Reduce Genetic Instabilities","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences","keywords":"Frataxin; DNA; Intron; Gene; Genetics; Nuclease; Biology; Escherichia coli; Ataxia; Molecular biology; Direct repeat; Transcription (linguistics); Trinucleotide repeat expansion; Chemistry; Iron-binding proteins; Allele; Base sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002481792,0.0001665416,0.0002757419,0.00005691986,0.00007233498,0.00004208079,0.0001303749,0.0001037251,0.00005369209],"category_scores_gemma":[0.001024736,0.0001053136,0.00007636329,0.0001693681,0.000352925,0.0001386832,0.00004421411,0.0002424542,1.836673e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003612626,"about_ca_system_score_gemma":0.00003713231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002699353,"about_ca_topic_score_gemma":0.000003209885,"domain_scores_codex":[0.9984266,0.0001988954,0.0007233068,0.0002418304,0.0002263348,0.0001829872],"domain_scores_gemma":[0.9990822,0.0001839819,0.0003991832,0.0001310978,0.000106769,0.00009678597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003156805,0.00007428152,0.002126412,0.00006639912,0.000003346179,0.00003092957,0.0002749295,0.00008046804,0.9953894,0.000008349549,0.00002193272,0.001607897],"study_design_scores_gemma":[0.001033442,0.0002056947,0.07155793,0.00007633342,0.00001659507,0.0006307128,0.0002811762,0.0001364215,0.9250271,0.0008754357,0.00005623448,0.0001028775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981775,0.0009104297,0.0002089823,0.0003942405,0.00004737821,0.0001758099,0.00002211254,0.00000774619,0.0000557658],"genre_scores_gemma":[0.9982191,0.001443534,0.00006581983,0.0001664874,0.00006580955,0.00000516367,0.000004169235,0.000006590107,0.0000232706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07036223,"threshold_uncertainty_score":0.4294563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04712634227196113,"score_gpt":0.2678164514971052,"score_spread":0.2206901092251441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}